UniProt Accession

 GCSH_MOUSE; Q91WK5; Q9CY75; Q9D197 

Genbank Protein ID

 AK003788; AK019983; AK050373; AC162858; CH466525; BC014745 

Genbank Nucleotide ID

 BAB22996.2; BAB31951.1; BAC34217.1; EDL11574.1; AAH14745.1 

Protein Name

 Glycine cleavage system H protein, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Gcsh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
163	MSEEAYEKYVKSIEE	acetylation	[1, 2]
166	EAYEKYVKSIEE***	acetylation	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity). 

Sequence Annotation

 MOD_RES 104 104 N6-lipoyllysine (By similarity).  

Keyword

 3D-structure; Complete proteome; Lipoyl; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005960; C:glycine cleavage complex; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004047; F:aminomethyltransferase activity; IEA:Compara.
 GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:Compara. 

Interpro

 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR002930; GCV_H.
 IPR017453; GCV_H_sub.
 IPR011053; Single_hybrid_motif. 

Pfam

 PF01597; GCV_H 

SMART

  

PROSITE

 PS00189; LIPOYL 

PRINTS