| Tag | Content |
|---|
| CPLM ID | CPLM-008141 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Homoaconitase, mitochondrial |
Protein Synonyms/Alias | Homoaconitate hydratase |
Gene Name | LYS4 |
Gene Synonyms/Alias | LYS3; YDR234W; YD8419.01; YD9934.18 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 76 | GLGATKIKNPSQIVT | acetylation | [1] | | 258 | KTLIDWYKNRLQKLG | acetylation | [1] | | 439 | FKGRMGSKDALAYLA | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Responsible for the dehydration of cis-homoaconitate to homoisocitric acid. |
Sequence Annotation | METAL 340 340 Iron-sulfur (4Fe-4S) (By similarity).
METAL 407 407 Iron-sulfur (4Fe-4S) (By similarity).
METAL 410 410 Iron-sulfur (4Fe-4S) (By similarity). |
Keyword | Amino-acid biosynthesis; Complete proteome; Iron; Iron-sulfur; Lyase; Lysine biosynthesis; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 693 AA |
Protein Sequence | MLRSTTFTRS FHSSRAWLKG QNLTEKIVQS YAVNLPEGKV VHSGDYVSIK PAHCMSHDNS 60
WPVALKFMGL GATKIKNPSQ IVTTLDHDIQ NKSEKNLTKY KNIENFAKKH HIDHYPAGRG 120
IGHQIMIEEG YAFPLNMTVA SDSHSNTYGG LGSLGTPIVR TDAAAIWATG QTWWQIPPVA 180
QVELKGQLPQ GVSGKDIIVA LCGLFNNDQV LNHAIEFTGD SLNALPIDHR LTIANMTTEW 240
GALSGLFPVD KTLIDWYKNR LQKLGTNNHP RINPKTIRAL EEKAKIPKAD KDAHYAKKLI 300
IDLATLTHYV SGPNSVKVSN TVQDLSQQDI KINKAYLVSC TNSRLSDLQS AADVVCPTGD 360
LNKVNKVAPG VEFYVAAASS EIEADARKSG AWEKLLKAGC IPLPSGCGPC IGLGAGLLEP 420
GEVGISATNR NFKGRMGSKD ALAYLASPAV VAASAVLGKI SSPAEVLSTS EIPFSGVKTE 480
IIENPVVEEE VNAQTEAPKQ SVEILEGFPR EFSGELVLCD ADNINTDGIY PGKYTYQDDV 540
PKEKMAQVCM ENYDAEFRTK VHPGDIVVSG FNFGTGSSRE QAATALLAKG INLVVSGSFG 600
NIFSRNSINN ALLTLEIPAL IKKLREKYQG APKELTRRTG WFLKWDVADA KVVVTEGSLD 660
GPVILEQKVG ELGKNLQEII VKGGLEGWVK SQL 693 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro. GO:0004409; F:homoaconitate hydratase activity; ISA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |