UniProt Accession

 B0QYQ2_HUMAN; B0QYQ2 

Genbank Protein ID

 AL034548 

Genbank Nucleotide ID

  

Protein Name

 Tribbles homolog 3 

Protein Synonyms/Alias

  

Gene Name

 TRIB3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	DTERPVQKRARSGPQ	ubiquitination	[1]
97	TGTEYTCKVYPVQEA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0055106; F:ubiquitin-protein ligase regulator activity; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara.
 GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IEA:Compara.
 GO:0010827; P:regulation of glucose transport; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR024104; Tribbles/Ser_Thr_kinase_40.
 IPR024106; Tribbles_TRB3. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM 

PRINTS