| Tag | Content |
|---|
| CPLM ID | CPLM-015267 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sterile alpha and TIR motif-containing protein 1 |
Protein Synonyms/Alias | Tir-1 homolog; MyD88-5 |
Gene Name | Sarm1 |
Gene Synonyms/Alias | Kiaa0524 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 363 | KSLQGKTKVFSDIGA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent activation of NF- kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis. |
Sequence Annotation | DOMAIN 412 476 SAM 1.
DOMAIN 486 548 SAM 2.
DOMAIN 559 657 TIR. |
Keyword | Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; Differentiation; Immunity; Innate immunity; Mitochondrion; Neurogenesis; Reference proteome; Repeat; Synapse; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 724 AA |
Protein Sequence | MVLTLLFSAY KLCRFFTMSG PRPGADRLTV PGPDRSGGAS PWWAAGGRGS REVSPGVGTE 60
VQGALERSLP ELQQALSELK QASAARAVGA GLAEVFQLVE EAWLLPAVGR EVAQGLCDAI 120
RLDGGLDLLL RLLQAPELET RVQAARLLEQ ILVAENRDRV ARIGLGVILN LAKEREPVEL 180
ARSVAGILEH MFKHSEETCQ RLVAAGGLDA VLYWCRRTDP ALLRHCALAL ANCALHGGQT 240
VQRCMVEKRA AEWLFPLAFS KEDELLRLHA CLAVAVLATN KEVEREVEHS GTLALVEPLV 300
ASLDPGRFAR CLVDASDTSQ GRGPDDLQSL VLLLDSSRLE AQCIGAFYLC AEAAIKSLQG 360
KTKVFSDIGA IQSLKRLVSY STNGTTSALA KRALRLLGEE VPRRILPCVA SWKEAEVQTW 420
LQQIGFSQYC ENFREQQVDG DLLLRLTDEE LQTDLGMKSS ITRKRFFREL TELKTFASYA 480
TCDRSNLADW LGSLDPRFRQ YTYGLVSCGL DRSLLHRVSE QQLLEDCGIR LGVHRTRILS 540
AAREMLHSPL PCTGGKLSGD TPDVFISYRR NSGSQLASLL KVHLQLHGFS VFIDVEKLEA 600
GKFEDKLIQS VIAARNFVLV LSAGALDKCM QDHDCKDWVH KEIVTALSCG KNIVPIIDGF 660
EWPEPQALPE DMQAVLTFNG IKWSHEYQEA TIEKIIRFLQ GRPSQDSSAG SDTSLEGATP 720
MGLP 724 |
Gene Ontology | GO:0030424; C:axon; IEA:UniProtKB-SubCell. GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0030425; C:dendrite; IMP:UniProtKB. GO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:MGI. GO:0005874; C:microtubule; IDA:UniProtKB. GO:0045202; C:synapse; IDA:UniProtKB. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0042981; P:regulation of apoptotic process; IMP:MGI. GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB. GO:1901214; P:regulation of neuron death; IMP:UniProtKB. GO:0009749; P:response to glucose stimulus; IMP:MGI. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |