| Tag | Content |
|---|
| CPLM ID | CPLM-017821 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane emp24 domain-containing protein 4 |
Protein Synonyms/Alias | Endoplasmic reticulum stress-response protein 25; ERS25; p24 family protein alpha-3; p24alpha3; p26 |
Gene Name | Tmed4 |
Gene Synonyms/Alias | Ers25 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 152 | PEIAAKDKLTELQLR | ubiquitination | [1] | | 172 | DQVEQIQKEQDYQRY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). |
Sequence Annotation | DOMAIN 39 137 GOLD.
MOTIF 220 227 COPI vesicle coat-binding (Potential).
MOTIF 220 221 COPII vesicle coat-binding (Potential).
CARBOHYD 117 117 N-linked (GlcNAc...) (Potential). |
Keyword | Coiled coil; Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 227 AA |
Protein Sequence | MAGVGVGPLQ GMVRFGLLVL TVCAACARGL YFHIGETEKR CFIEEIPDET MVIGNYRTQM 60
WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF TFTSHTPGDH QICLHSNSTR 120
MALFAGGKLR VHLDIQVGEH ANNYPEIAAK DKLTELQLRA RQLLDQVEQI QKEQDYQRYR 180
EERFRLTSES TNQRVLWWSI AQTVILILTG IWQMRHLKSF FEAKKLV 227 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; IEA:Compara. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |