UniProt Accession

 UB2G1_MOUSE; P62254; Q4VAA6; Q99462 

Genbank Protein ID

 AK013902; BC096474 

Genbank Nucleotide ID

 BAB29048.1; AAH96474.1 

Protein Name

 Ubiquitin-conjugating enzyme E2 G1 

Protein Synonyms/Alias

 E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1 

Gene Name

 Ube2g1 

Gene Synonyms/Alias

 Ube2g 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
73	PLRPPKMKFITEIWH	ubiquitination	[1]
101	LHEPGEDKYGYEKPE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4 (By similarity). 

Sequence Annotation

 ACT_SITE 90 90 Glycyl thioester intermediate (By
 MOD_RES 2 2 N-acetylthreonine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
 GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS