Tag | Content |
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CPLM ID | CPLM-013339 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Small RNA 2'-O-methyltransferase |
Protein Synonyms/Alias | HEN1 methyltransferase homolog 1 |
Gene Name | HENMT1 |
Gene Synonyms/Alias | QtsA-13748 |
Created Date | July 27, 2013 |
Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
NCBI Taxa ID | 9541 |
Lysine Modification | Position | Peptide | Type | References |
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50 | VDQHEPKKVADLGCG | ubiquitination | [1] |
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Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). |
Sequence Annotation | METAL 132 132 Magnesium (By similarity). METAL 135 135 Magnesium (By similarity). METAL 136 136 Magnesium; via tele nitrogen (By METAL 181 181 Magnesium; via tele nitrogen (By BINDING 60 60 S-adenosyl-L-methionine (By similarity). BINDING 78 78 S-adenosyl-L-methionine (By similarity). BINDING 114 114 S-adenosyl-L-methionine (By similarity). |
Keyword | Cytoplasm; Metal-binding; Methyltransferase; RNA-binding; RNA-mediated gene silencing; S-adenosyl-L-methionine; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 393 AA |
Protein Sequence | MEENNLQCSS VVDGNFEEVP RETAIQFKPP LYRQRYQFVK NLVDQHEPKK VADLGCGDTS 60 LLRLLKVNPC IELLVGVDIN EDKLRWRGDS LAPFMGDFLK PRDLNLTIIL YHGSVVERDS 120 RLLGFDLITC IELIEHLDSG DLARFPEVVF GYLSPSMIVI STPNSEFNPL FPSVTLRDSD 180 HKFEWTRMEF QTWALYVANR YDYSVEFTGV GEPPAGAENV GYCTQIGIFQ KNGGRATEAC 240 VSEQHDQHVY KAVFTTSYPS LQQERFFKLV LVNEVSQQVE SLRVSHLPRR KEQDGEQGDK 300 PKDIGGSKAP VPCFGPVFTE VEKAKIENSP KPFCVGDKFF VPLQRLLAYP RLNRLCANEE 360 MMRSVIADSI PLSSDGSAVV TDLCNYFDEQ FEF 393 |
Gene Ontology | GO:0043186; C:P granule; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008171; F:O-methyltransferase activity; ISS:UniProtKB. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0008173; F:RNA methyltransferase activity; ISS:UniProtKB. GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW. GO:0034587; P:piRNA metabolic process; ISS:UniProtKB. |
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