UniProt Accession

 PPLA_MOUSE; P61014; P20006; Q3UQ75 

Genbank Protein ID

 S46792; AK002622; AK040718; AK052199; AK142708; BC061097 

Genbank Nucleotide ID

 AAB23706.1; BAB22237.1; BAC30680.1; BAC34880.1; BAE25168.1; AAH61097.1 

Protein Name

 Cardiac phospholamban 

Protein Synonyms/Alias

 PLB 

Gene Name

 Pln 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MEKVQYLTRS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 16 16 Phosphoserine; by PKA and DMPK (By
 MOD_RES 17 17 Phosphothreonine; by CaMK2 (By  

Keyword

 3D-structure; Acetylation; Complete proteome; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 52 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0042030; F:ATPase inhibitor activity; IEA:Compara.
 GO:0005246; F:calcium channel regulator activity; IEA:InterPro.
 GO:0086023; P:adrenergic receptor signaling pathway involved in heart process; IMP:MGI.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IGI:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
 GO:0045822; P:negative regulation of heart contraction; IMP:MGI.
 GO:0090279; P:regulation of calcium ion import; IMP:MGI.
 GO:0086004; P:regulation of cardiac muscle cell contraction; IMP:MGI.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IMP:MGI.
 GO:1901077; P:regulation of relaxation of muscle; IMP:MGI.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IMP:MGI.
 GO:0086092; P:regulation of the force of heart contraction by cardiac conduction; IMP:MGI. 

Interpro

 IPR005984; P_lamban. 

Pfam

 PF04272; Phospholamban 

SMART

  

PROSITE

  

PRINTS