CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-045141
UniProt Accession
K7ERP4_HUMAN
;
K7ERP4
Genbank Protein ID
AC004151
Genbank Nucleotide ID
Protein Name
Glutathione peroxidase
Protein Synonyms/Alias
Gene Name
GPX4
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
127
AIKWNFT
K
FLIDKNG
ubiquitination
[1]
Reference
[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [
PMID: 21890473
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Oxidoreductase; Peroxidase; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
155 AA
Protein Sequence
MHEFSAKDID GHMVNLDKYR GFVCIVTNVA SQCGKTEVNY TQLVDLHARY AECGLRILAF 60
PCNQFGKQEP GSNEEIKEFA AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA 120
IKWNFTKFLI DKNGCVVKRY GPMEEPLVIE KDLPH 155
Gene Ontology
GO:0004602
; F:glutathione peroxidase activity; IEA:InterPro.
GO:0006979
; P:response to oxidative stress; IEA:InterPro.
Interpro
IPR000889
; Glutathione_peroxidase.
IPR012336
; Thioredoxin-like_fold.
Pfam
PF00255
; GSHPx
SMART
PROSITE
PS00460
; GLUTATHIONE_PEROXID_1
PS00763
; GLUTATHIONE_PEROXID_2
PS51355
; GLUTATHIONE_PEROXID_3
PRINTS
PR01011
; GLUTPROXDASE.