UniProt Accession

 AAAD_MOUSE; Q99PG0; Q8VCF2 

Genbank Protein ID

 AF306788; BC019999; BC054823 

Genbank Nucleotide ID

 AAG60035.1; AAH19999.1; AAH54823.1 

Protein Name

 Arylacetamide deacetylase 

Protein Synonyms/Alias

  

Gene Name

 Aadac 

Gene Synonyms/Alias

 Aada 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
149	TDYGLAPKHHFPRQF	ubiquitination	[1]
174	LQEDVLEKYGVDPRR	ubiquitination	[1]
208	LIQDPDVKIKLKVQA	ubiquitination	[1]
297	YKKSPVYKNPTPGSS	ubiquitination	[1]
309	GSSELAQKYPGFIDV	ubiquitination	[1]
317	YPGFIDVKACPLLAN	ubiquitination	[1]
333	NILHHLPKTYIITCQ	acetylation	[2]
396	QYLSWLIKNL*****	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens (By similarity). Displays major serine hydrolase activity in liver microsomes. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. 

Sequence Annotation

 ACT_SITE 110 110 Potential.
 ACT_SITE 188 188 Potential.
 CARBOHYD 281 281 N-linked (GlcNAc...) (Potential).
 DISULFID 115 339 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Microsome; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004091; F:carboxylesterase activity; IEA:InterPro.
 GO:0019213; F:deacetylase activity; ISS:UniProtKB.
 GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC.
 GO:0017171; F:serine hydrolase activity; IDA:UniProtKB.
 GO:0004806; F:triglyceride lipase activity; IDA:UniProtKB.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IDA:UniProtKB. 

Interpro

 IPR013094; AB_hydrolase_3.
 IPR017157; Arylacetamide_deacetylase.
 IPR002168; Lipase_GDXG_AS. 

Pfam

 PF07859; Abhydrolase_3 

SMART

  

PROSITE

 PS01173; LIPASE_GDXG_HIS
 PS01174; LIPASE_GDXG_SER 

PRINTS