CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ankyrin repeat and LEM domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 ANKLE2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
11DALLARLKLLNPDDLubiquitination[1]
28EIVKAGLKCGPITSTubiquitination[1, 2]
132RAGATASKEPPLYYGubiquitination[1]
209SLPLSPVKTAPLFSNubiquitination[1]
250RTQDLTAKLRKAVEKubiquitination[1]
377SSHHLIVKNSRNKYDubiquitination[1]
385NSRNKYDKTPEDVICubiquitination[1]
469AGPLSPAKAEDFRKLubiquitination[1]
484WKTPPREKAGFLHHVubiquitination[1]
548LTQQEIGKKAQQETGubiquitination[1]
564REASCRDKATTSGSNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 876 AA 
Protein Sequence
MTMDALLARL KLLNPDDLRE EIVKAGLKCG PITSTTRFIF EKKLAQALLE QGGRLSSFYH 60
HEAGVTALSQ DPQRILKPAE GNPTDQAGFS EDRDFGYSVG LNPPEEEAVT SKTCSVPPSD 120
TDTYRAGATA SKEPPLYYGV CPVYEDVPAR NERIYVYENK KEALQAVKMI KGSRFKAFST 180
REDAEKFARG ICDYFPSPSK TSLPLSPVKT APLFSNDRLK DGLCLSESET VNKERANSYK 240
NPRTQDLTAK LRKAVEKGEE DTFSDLIWSN PRYLIGSGDN PTIVQEGCRY NVMHVAAKEN 300
QASICQLTLD VLENPDFMRL MYPDDDEAML QKRIRYVVDL YLNTPDKMGY DTPLHFACKF 360
GNADVVNVLS SHHLIVKNSR NKYDKTPEDV ICERSKNKSV ELKERIREYL KGHYYVPLLR 420
AEETSSPVIG ELWSPDQTAE ASHVSRYGGS PRDPVLTLRA FAGPLSPAKA EDFRKLWKTP 480
PREKAGFLHH VKKSDPERGF ERVGRELAHE LGYPWVEYWE FLGCFVDLSS QEGLQRLEEY 540
LTQQEIGKKA QQETGEREAS CRDKATTSGS NSISVRAFLD EDDMSLEEIK NRQNAARNNS 600
PPTVGAFGHT RCSAFPLEQE ADLIEAAEPG GPHSSRNGLC HPLNHSRTLA GKRPKAPRGE 660
EAHLPPVSDL TVEFDKLNLQ NIGRSVSKTP DESTKTKDQI LTSRINAVER DLLEPSPADQ 720
LGNGHRRTES EMSARIAKMS LSPSSPRHED QLEVTREPAR RLFLFGEEPS KLDQDVLAAL 780
ECADVDPHQF PAVHRWKSAV LCYSPSDRQS WPSPAVKGRF KSQLPDLSGP HSYSPGRNSV 840
AGSNPAKPGL GSPGRYSPVH GSQLRRMARL AELAAL 876 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom.
 IPR011320; RNase_H1_N. 
Pfam
 PF12796; Ank_2
 PF03020; LEM 
SMART
 SM00248; ANK 
PROSITE
 PS50954; LEM 
PRINTS