CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016862
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein unc-45 homolog B 
Protein Synonyms/Alias
 Unc-45B 
Gene Name
 Unc45b 
Gene Synonyms/Alias
 Cmya4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
39ALKLTKDKALLATLYubiquitination[1]
600PELVQLAKFSKQHVPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. 
Sequence Annotation
 REPEAT 6 39 TPR 1.
 REPEAT 43 76 TPR 2.
 REPEAT 77 110 TPR 3.
 REPEAT 169 208 ARM 1.
 REPEAT 211 250 ARM 2.
 REPEAT 751 790 ARM 3.  
Keyword
 Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 931 AA 
Protein Sequence
MAEAEAAQLK EEGNRHFQLQ DYKAATKSYS QALKLTKDKA LLATLYRNRA ACGLKMESYA 60
QAASDASRAI DINSADIKAL YRRCQALEHL GKLDQAFKDV QRCATLEPRN QNFQETLRRL 120
NTSIQEQLRV QFSTDSRVQT MFEILLNENS EADKREKAAN NLIVLGREEA GAERIFQSNG 180
VALLLQLMNT QRPELLLAAV RTLSGMCSGH RARATAILHA VRIDRICSLM ALENEEMSLA 240
VCNLLQAIID SLSGEDKREH RGKEEALVLD TKKDLKQITS HLLDMLVSKK VSGQGRDQAL 300
NLLNKNVPRK DLSIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN TRMLASILIN 360
KLYDDLRCDP ERDHFRKICE EYITSKFDPQ DMDKNVNAIQ TVSGILQGPF DLGNQLLGMK 420
GVMEMMVALC GSEREADQLV AVEALIHAST KLSRATFIIT NGVTLLKQIY KTTKNEKIKI 480
RTLVGLCKLG SAGGSDYGLR QFAEGSTEKL AKQCRKWLCN TAIDTRTRRW AVEGLAYLTL 540
DADVKDDFVQ DIPALQAMFE LAKARTSDKT ILYSVANTLV NCTNSYDVKE VVPELVQLAK 600
FSKQHVPEEH PKDKKDFVDL RVKRLLKAGV ISALACMVKA DSAILTDQTK ELLARVFLAL 660
CDNPKDRGTI VAQGGGKALI PLALEGTDVG KVKAAHGLAK IAAVSNPDIA FPGERVYEVV 720
RPLVSLLDTQ RDGLQNYEAL LGLTNLSGRS DKLRQKIFKE KALPDIENYM FENHDQLRQA 780
ATECMCNMVL NKEVQERFLA DGNDRLKLVV LLCGEDDHKL QNAAAGALAM LTAAHKKLCL 840
KMTEVTTQWL EILQRLCLHD QLSVQHRGLV IAHNLLSADA ELARKLVESE LLEILTVVGK 900
QEPDEKRAAV VQTARECLIK CMDYGFIKPV S 931 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0051879; F:Hsp90 protein binding; IDA:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0061077; P:chaperone-mediated protein folding; IDA:MGI.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR024660; UNC-45/Ring3. 
Pfam
 PF00515; TPR_1
 PF11701; UNC45-central 
SMART
 SM00028; TPR 
PROSITE
 PS50176; ARM_REPEAT
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS