UniProt Accession

 PTER_HUMAN; Q96BW5; B0YJ77; B3KTF5; D3DRU0; Q9BY46 

Genbank Protein ID

 AF212237; AK095486; AK314910; EF445015; EF445015; EF445015; AL360230; CH471072; CH471072; CH471072; CH471072; CH471072; BC015092; BC050411 

Genbank Nucleotide ID

 AAK14923.1; BAG53067.1; BAG37422.1; ACA06055.1; ACA06056.1; ACA06057.1; CAH73146.1; EAW86226.1; EAW86229.1; EAW86227.1; EAW86228.1; EAW86230.1; AAH15092.1; AAH50411.1 

Protein Name

 Phosphotriesterase-related protein 

Protein Synonyms/Alias

 Parathion hydrolase-related protein; hPHRP 

Gene Name

 PTER 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MSSLSGKVQTVLGL	ubiquitination	[1]
19	LGLVEPSKLGRTLTH	ubiquitination	[1, 2, 3, 4, 5, 6]
62	KNLYWIQKNAYSHKE	ubiquitination	[1]
81	NQETEAIKEELLYFK	ubiquitination	[2, 5]
88	KEELLYFKANGGGAL	ubiquitination	[2]
111	SRDTQTLKRLAEETG	ubiquitination	[2]
225	EAGADISKTVMSHLD	ubiquitination	[1, 2]
238	LDRTILDKKELLEFA	ubiquitination	[2]
302	VAHDIHTKTRLMKYG	ubiquitination	[1, 2, 3]
336	ITENVLDKILIENPK	ubiquitination	[2]
343	KILIENPKQWLTFK*	ubiquitination	[1, 2, 4, 5, 6]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

 METAL 26 26 Divalent metal cation 1 (By similarity).
 METAL 28 28 Divalent metal cation 1 (By similarity).
 METAL 169 169 Divalent metal cation 1 (By similarity).
 METAL 169 169 Divalent metal cation 2 (By similarity).
 METAL 201 201 Divalent metal cation 2 (By similarity).
 METAL 230 230 Divalent metal cation 2 (By similarity).
 METAL 298 298 Divalent metal cation 1 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009056; P:catabolic process; IEA:InterPro. 

Interpro

 IPR017947; AryldialkylPase_Zn-BS.
 IPR001559; Aryldialkylphosphatase. 

Pfam

 PF02126; PTE 

SMART

  

PROSITE

 PS01322; PHOSPHOTRIESTERASE_1
 PS51347; PHOSPHOTRIESTERASE_2 

PRINTS