UniProt Accession

 KAD1_RAT; P39069; Q5EBC5; Q9JJN3 

Genbank Protein ID

 AB022701; BC089797; D13376 

Genbank Nucleotide ID

 BAA97655.1; AAH89797.1; BAA02643.1 

Protein Name

 Adenylate kinase isoenzyme 1 

Protein Synonyms/Alias

 AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase 

Gene Name

 Ak1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MEDKLKKAKII	acetylation	[1]
6	**MEDKLKKAKIIFV	acetylation	[1]
100	DGYPREVKQGEEFER	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). 

Sequence Annotation

 NP_BIND 18 23 ATP (By similarity).
 NP_BIND 65 67 AMP (By similarity).
 NP_BIND 94 97 AMP (By similarity).
 REGION 38 67 NMPbind (By similarity).
 REGION 131 141 LID (By similarity).
 BINDING 39 39 AMP (By similarity).
 BINDING 44 44 AMP (By similarity).
 BINDING 101 101 AMP (By similarity).
 BINDING 132 132 ATP (By similarity).
 BINDING 138 138 AMP (By similarity).
 BINDING 149 149 AMP (By similarity).
 BINDING 177 177 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0030017; C:sarcomere; IDA:RGD.
 GO:0004017; F:adenylate kinase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046083; P:adenine metabolic process; NAS:RGD.
 GO:0006172; P:ADP biosynthetic process; IDA:RGD.
 GO:0046033; P:AMP metabolic process; IDA:RGD.
 GO:0046034; P:ATP metabolic process; IEA:InterPro.
 GO:0021549; P:cerebellum development; IEP:RGD.
 GO:0046103; P:inosine biosynthetic process; IDA:RGD.
 GO:0007517; P:muscle organ development; IEP:RGD.
 GO:0030182; P:neuron differentiation; IEP:RGD.
 GO:0021772; P:olfactory bulb development; IEP:RGD.
 GO:0010828; P:positive regulation of glucose transport; IMP:RGD.
 GO:0014042; P:positive regulation of neuron maturation; IEP:RGD.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0033574; P:response to testosterone stimulus; IEP:RGD. 

Interpro

 IPR000850; Adenylate_kin.
 IPR006267; Adenylate_kin1.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.