| Tag | Content |
|---|
| CPLM ID | CPLM-023423 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase |
Protein Synonyms/Alias | InsP6 and PP-IP5 kinase |
Gene Name | l(1)G0196 |
Gene Synonyms/Alias | CG14616 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 505 | INRKVQMKYQPKGRP | acetylation | [1] | | 642 | DNDCDSSKYQNLAKG | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP- InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). |
Sequence Annotation | NP_BIND 260 263 ATP (By similarity).
NP_BIND 269 271 ATP (By similarity).
NP_BIND 344 346 ATP (By similarity).
REGION 76 77 Substrate binding (By similarity).
REGION 236 237 Substrate binding (By similarity).
REGION 349 352 Substrate binding (By similarity).
BINDING 157 157 ATP (By similarity).
BINDING 210 210 ATP (By similarity).
BINDING 217 217 ATP (By similarity).
BINDING 236 236 ATP (By similarity).
BINDING 271 271 Substrate (By similarity).
BINDING 285 285 Substrate (By similarity).
BINDING 287 287 ATP (By similarity).
BINDING 332 332 ATP (By similarity).
MOD_RES 974 974 Phosphoserine.
MOD_RES 1001 1001 Phosphoserine.
MOD_RES 1060 1060 Phosphoserine.
MOD_RES 1255 1255 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; RNA editing; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1696 AA |
Protein Sequence | MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 60
SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 120
VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 180
SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 240
RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 300
KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 360
CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 420
MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 480
KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 540
ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 600
MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 660
FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 720
HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 780
AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 840
GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 900
IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 960
DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 1020
IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 1080
PTSGVCAKEP DSQVSVSVSA SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS 1140
ANSLFSTAVI SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL 1200
AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF DRRGSESGST 1260
ADAHLRLLSE SQCPNLDDSN TELRESLAGK MELWPQDIVK AAEDEELNLS ELETKPSLDL 1320
TMEIMERGVA GIASIQPMNR DSDETMGGGV FLSVCEEQGS GSTCLTPVSF GMDLDLSMVA 1380
NKGSITLSME GFDDDEDATL SAATTPSLLA DCEPRLESCY CCPSHAEAPP EVPSDDPRFG 1440
FALPVRVTQA SPEHARPVRR AHDPVSPRIQ KQISLFEGNA AMATGQEKTE SSGSVGGGAI 1500
LHASINLPAA GPHHLRQDAR LRKFENLTQS TSNSNFPFES NTLKRVPMQT TKDYDNVSHT 1560
QSCINLKSGS SGVLGGSPQR QRGSDGGGVG ASGVPAESRE PTRVHYGRMN STCCSASASP 1620
SPSPGALIVK ERFIEPPKRG VVRGYHGKTQ SMDADFLFNE FLLLPAMAPA KISFDSSDID 1680
QASDDDSPSS SKQRHA 1696 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0033857; F:diphosphoinositol-pentakisphosphate kinase activity; ISS:UniProtKB. GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:EC. GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:EC. GO:0000832; F:inositol hexakisphosphate 5-kinase activity; ISS:UniProtKB. GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; ISS:UniProtKB. GO:0016301; F:kinase activity; IEA:UniProtKB-KW. GO:0006020; P:inositol metabolic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |