UniProt Accession

 CARD8_HUMAN; Q9Y2G2; B5KVR6; B7Z496; B7Z4A2; E9PEM7; G3XAM9; Q6PGP8; Q96P82 

Genbank Protein ID

 AB023172; AF322184; AF331519; AY026322; AF405558; EU118120; AF511652; AK297045; AK297069; AC008392; AC011466; CH471177; CH471177; BC056891 

Genbank Nucleotide ID

 BAA76799.2; AAG50014.1; AAK01126.1; AAK08982.1; AAL02427.1; ABW96891.1; AAM46959.1; BAH12482.1; BAH12488.1; EAW52321.1; EAW52323.1; AAH56891.1 

Protein Name

 Caspase recruitment domain-containing protein 8 

Protein Synonyms/Alias

 Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN 

Gene Name

 CARD8 

Gene Synonyms/Alias

 KIAA0955; NDPP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	FEIEEDYKNRQFLGP	ubiquitination	[1]
70	VDVELIDKSTNRYSV	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. 

Sequence Annotation

 DOMAIN 340 430 CARD.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0072559; C:NLRP3 inflammasome complex; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:HGNC.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:HGNC.
 GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:HGNC. 

Interpro

 IPR001315; CARD.
 IPR011029; DEATH-like_dom.
 IPR025307; FIIND_dom. 

Pfam

 PF00619; CARD
 PF13553; FIIND 

SMART

 SM00114; CARD 

PROSITE

 PS50209; CARD 

PRINTS