UniProt Accession

 RRAGD_HUMAN; Q9NQL2; A8K184; Q7L8F9; Q9NPG0 

Genbank Protein ID

 AF272036; AK289799; AL138717; AL138717; CH471051; AL137502; BC003088 

Genbank Nucleotide ID

 AAG32663.1; BAF82488.1; CAB99361.1; CAB99362.1; EAW48554.1; CAB70775.2; AAH03088.1 

Protein Name

 Ras-related GTP-binding protein D 

Protein Synonyms/Alias

 Rag D; RagD 

Gene Name

 RRAGD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	SGKSSIQKVVFHKMS	ubiquitination	[1, 2]
330	NTTVLYLKEVTKFLA	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. 

Sequence Annotation

 NP_BIND 69 77 GTP.
 NP_BIND 117 121 GTP.
 NP_BIND 179 182 GTP.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; GTP-binding; Lysosome; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; NAS:UniProtKB. 

Interpro

 IPR006762; Gtr1_RagA.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04670; Gtr1_RagA 

SMART

  

PROSITE

  

PRINTS