UniProt Accession

 CD2B2_HUMAN; O95400; B2RDX2; Q9ULP2 

Genbank Protein ID

 AF104222; AK315708; CH471192; BC000495; BC001947; AB033004 

Genbank Nucleotide ID

 AAC84141.1; BAG38069.1; EAW52260.1; AAH00495.1; AAH01947.1; BAA86492.1 

Protein Name

 CD2 antigen cytoplasmic tail-binding protein 2 

Protein Synonyms/Alias

 CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; U5 snRNP 52K protein; U5-52K 

Gene Name

 CD2BP2 

Gene Synonyms/Alias

 KIAA1178 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	LDNIDWVKIRERPPG	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. 

Sequence Annotation

 DOMAIN 280 338 GYF.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 195 195 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005654; C:nucleoplasm; IDA:BHF-UCL.
 GO:0005682; C:U5 snRNP; IDA:BHF-UCL.
 GO:0043021; F:ribonucleoprotein complex binding; IDA:BHF-UCL.
 GO:0000244; P:assembly of spliceosomal tri-snRNP; NAS:BHF-UCL.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. 

Interpro

 IPR003169; GYF. 

Pfam

 PF02213; GYF 

SMART

 SM00444; GYF 

PROSITE

 PS50829; GYF 

PRINTS