UniProt Accession

 DCOR_HUMAN; P11926; Q53TU3; Q6LDS9 

Genbank Protein ID

 M16650; M31061; X16277; M33764; M34158; M81740; X55362; AK292352; AK312766; AY841870; AC007249; CH471053; CH471053; BC025296; X53271; M20372 

Genbank Nucleotide ID

 AAA59966.2; AAA60563.1; CAA34353.1; AAA60564.1; AAA59969.1; AAA59967.1; CAA39047.1; BAF85041.1; BAG35632.1; AAV88093.1; AAY15034.1; EAX00958.1; EAX00959.1; AAH25296.1; CAA37369.1; AAA59968.1 

Protein Name

 Ornithine decarboxylase 

Protein Synonyms/Alias

 ODC 

Gene Name

 ODC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	AKDILDQKINEVSSS	ubiquitination	[1]
50	ADLGDILKKHLRWLK	ubiquitination	[1, 2]
51	DLGDILKKHLRWLKA	ubiquitination	[2]
57	KKHLRWLKALPRVTP	ubiquitination	[2]
69	VTPFYAVKCNDSKAI	ubiquitination	[2]
74	AVKCNDSKAIVKTLA	ubiquitination	[2]
78	NDSKAIVKTLAATGT	ubiquitination	[2]
115	IIYANPCKQVSQIKY	ubiquitination	[2]
141	DSEVELMKVARAHPK	ubiquitination	[2]
150	ARAHPKAKLVLRIAT	ubiquitination	[2]
161	RIATDDSKAVCRLSV	ubiquitination	[2]
247	GSEDVKLKFEEITGV	ubiquitination	[1]
261	VINPALDKYFPSDSG	ubiquitination	[1, 3]
345	PLLQKRPKPDEKYYS	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

 ACT_SITE 360 360 Proton donor; shared with dimeric
 MOD_RES 69 69 N6-(pyridoxal phosphate)lysine.
 MOD_RES 303 303 Phosphoserine; by CK2 (By similarity).
 MOD_RES 360 360 S-nitrosocysteine; in inhibited form  

Keyword

 3D-structure; Complete proteome; Decarboxylase; Lyase; Phosphoprotein; Polyamine biosynthesis; Pyridoxal phosphate; Reference proteome; S-nitrosylation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 461 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004586; F:ornithine decarboxylase activity; TAS:UniProtKB.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0006596; P:polyamine biosynthetic process; NAS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0033387; P:putrescine biosynthetic process from ornithine; IEA:UniProtKB-UniPathway.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0009615; P:response to virus; IEP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR009006; Ala_racemase/Decarboxylase_C.
 IPR022643; De-COase2_C.
 IPR022657; De-COase2_CS.
 IPR022644; De-COase2_N.
 IPR022653; De-COase2_pyr-phos_BS.
 IPR000183; Orn/DAP/Arg_de-COase.
 IPR002433; Orn_de-COase. 

Pfam

 PF02784; Orn_Arg_deC_N
 PF00278; Orn_DAP_Arg_deC 

SMART

  

PROSITE

 PS00878; ODR_DC_2_1
 PS00879; ODR_DC_2_2 

PRINTS

 PR01179; ODADCRBXLASE.
 PR01182; ORNDCRBXLASE.