| Tag | Content |
|---|
| CPLM ID | CPLM-040041 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 6-phosphogluconate dehydrogenase, decarboxylating |
Protein Synonyms/Alias | |
Gene Name | PGD |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 87 | AVDDFIEKLRRCRDL | ubiquitination | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity). |
Sequence Annotation | ACT_SITE 162 162 Proton acceptor (By similarity).
ACT_SITE 169 169 Proton donor (By similarity). |
Keyword | Complete proteome; NADP; Oxidoreductase; Pentose shunt; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE 60
MVSKLKKPRR IILLVKAGQA VDDFIEKLRR CRDLKAKGIL FVGSGVSGGE EGARYGPSLM 120
PGGNKEAWPH IKTIFQGIAA KVGTGEPCCD WVGDEGAGHF VKMVHNGIEY GDMQLICEAY 180
HLMKDVLGMA QDEMAQAFED WNKTELDSFL IEITANILKF QDTDGKHLLP KIRDSAGQKG 240
TGKWTAISAL EYGVPVTLIG EAVFARCLSS LKDERIQASK KLKGPQKFQF DGDKKSFLED 300
IRKALYASKI ISYAQGFMLL RQAATEFGWT LNYGGIALMW RGGCIIRSVF LGKIKDAFDR 360
NPELQNLLLD DFFKSAVENC QDSWRRAVST GVQAGIPMPC FTTALSFYDG YRHEMLPASL 420
IQAQRDYFGA HTYELLAKPG QFIHTNWTGH GGTVSSSSYN A 461 |
Gene Ontology | GO:0050661; F:NADP binding; IEA:InterPro. GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:EC. GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |