| Tag | Content |
|---|
| CPLM ID | CPLM-009786 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH-quinone oxidoreductase subunit E |
Protein Synonyms/Alias | NADH dehydrogenase I subunit E; NDH-1 subunit E |
Gene Name | nuoE |
Gene Synonyms/Alias | Rv3149; MT3237; MTCY03A2.09c |
Created Date | July 27, 2013 |
Organism | Mycobacterium tuberculosis |
NCBI Taxa ID | 1773 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 45 | ARLEVDAKEIIGRYP | pupylation | [1] |
|
Reference | [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] . Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH. PLoS One. 2010 Jan 6;5(1):e8589. [ PMID: 20066036] |
Functional Description | NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). |
Sequence Annotation | METAL 114 114 Iron-sulfur (2Fe-2S) (Potential).
METAL 119 119 Iron-sulfur (2Fe-2S) (Potential).
METAL 155 155 Iron-sulfur (2Fe-2S) (Potential).
METAL 159 159 Iron-sulfur (2Fe-2S) (Potential).
CROSSLNK 45 45 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | 2Fe-2S; Complete proteome; Iron; Iron-sulfur; Isopeptide bond; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 252 AA |
Protein Sequence | MTQPPGQPVF IRLGPPPDEP NQFVVEGAPR SYPPDVLARL EVDAKEIIGR YPDRRSALLP 60
LLHLVQGEDS YLTPAGLRFC ADQLGLTGAE VSAVASFYTM YRRRPTGEYL VGVCTNTLCA 120
VMGGDAIFDR LKEHLGVGHD ETTSDGVVTL QHIECNAACD YAPVVMVNWE FFDNQTPESA 180
RELVDSLRSD TPKAPTRGAP LCGFRQTSRI LAGLPDQRPD EGQGGPGAPT LAGLQVARKN 240
DMQAPPTPGA DE 252 |
Gene Ontology | GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:EC. GO:0048038; F:quinone binding; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |