UniProt Accession

 ENC1_HUMAN; O14682; B4DHJ1; E9PFU0; O75464; Q9UPG9 

Genbank Protein ID

 AF010314; AF005381; AF059611; AK295128; AC026405; BC000418 

Genbank Nucleotide ID

 AAC39532.1; AAC64498.1; AAC26109.1; BAG58153.1; AAH00418.1 

Protein Name

 Ectoderm-neural cortex protein 1 

Protein Synonyms/Alias

 ENC-1; Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein 

Gene Name

 ENC1 

Gene Synonyms/Alias

 KLHL37; NRPB; PIG10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
316	KLYLVDQKAKEIIPK	ubiquitination	[1]
318	YLVDQKAKEIIPKAD	ubiquitination	[1]
331	ADIPSPRKEFSACAI	ubiquitination	[2]
443	NAAVVSAKLKLFAFG	ubiquitination	[3]
520	SETYQWTKVGDVTAK	ubiquitination	[2, 3]
527	KVGDVTAKRMSCHAV	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism. 

Sequence Annotation

 DOMAIN 46 114 BTB.
 REPEAT 296 340 Kelch 1.
 REPEAT 341 388 Kelch 2.
 REPEAT 389 444 Kelch 3.
 REPEAT 446 492 Kelch 4.
 REPEAT 494 538 Kelch 5.
 REPEAT 539 585 Kelch 6.  

Keyword

 Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Kelch repeat; Nucleus; Polymorphism; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 589 AA 

Protein Sequence

Gene Ontology

 GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB. 

Interpro

 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR017096; Kelch-like_gigaxonin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS