CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 FERM, RhoGEF and pleckstrin domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Farp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
195EYLPNQEKSLEKILDubiquitination[1]
385ALTVDLPKQSVSFTDubiquitination[1]
782FSFQPNLKSSTPGKQubiquitination[1]
788LKSSTPGKQIDKNPSacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 795 AA 
Protein Sequence
MGEIEGTYRA LPTSGTRLGG QTAIGVSTLE PEQSLSPRMQ EKHMRIRVKL LDSTVELFDI 60
EPKCDGQVLL TQVWKHLNLI ECDYFGLEFK NVQSYWIWLE PMKPIIRQVR KPKNAVLRLA 120
VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCTANTA ALLISHLLQS EIGDYDETLD 180
REHLKANEYL PNQEKSLEKI LDFHQRHTGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE 240
GTKINLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL 300
GSRDECKNFW KICVEYHTFF RLSDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYVKDGGM 360
KRIPYERRHS KTRTSLHALT VDLPKQSVSF TDGLRTSASL SSANVSFYPP PSSSLSPPGL 420
PNLKDSSSSL VDPQAPVIKS TAAERSSGPS SSDGPSTQSA HLPGPPVLRP GPGAGFCGVN 480
SHGSACPRGQ SLNAVDISKG RTSRGLKAVR RKDSSEDEFS AGSFLPSGEY QGGQQCLRGV 540
PVFTLTNAQL QVSEEFIDDD PADISFFAGG SEAFSFPYSS LVLQESLLPV QSTGSPALCG 600
AESAQSSPDR YSTEAVDMSV EDDFEFGEGS DFNGNVHPSD TSELFEVKAQ ASLMQSLLSP 660
SETSSLRNNQ SENSSLNNMP LHGGFSLHTS SSANQSEASS MVNFPACSVR SESSSAFQFS 720
DIIDQLEQLS YPPTTAEGSS STDSDSWDSE AEAPLDMNLF FSNPFAQSSG ERVPFSFQPN 780
LKSSTPGKQI DKNPS 795 
Gene Ontology
 GO:0005737; C:cytoplasm; ISO:MGI.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISO:MGI.
 GO:0016322; P:neuron remodeling; ISO:MGI.
 GO:0016601; P:Rac protein signal transduction; ISO:MGI. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.