UniProt Accession

 RAP2C_HUMAN; Q9Y3L5; B3KWD6; Q5H9H9; Q9BTS0 

Genbank Protein ID

 AY298955; AL049685; AK124801; Z78022; CH471107; BC003403 

Genbank Nucleotide ID

 AAP55684.1; CAB41256.1; BAG54098.1; CAI42719.1; EAX11782.1; AAH03403.1 

Protein Name

 Ras-related protein Rap-2c 

Protein Synonyms/Alias

  

Gene Name

 RAP2C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MREYKVVVLGSG	ubiquitination	[1, 2, 3]
31	VTGTFIEKYDPTIED	ubiquitination	[4]
108	VRVKRYEKVPLILVG	ubiquitination	[2, 3]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (Probable).
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 180 180 Cysteine methyl ester (By similarity).
 LIPID 180 180 S-geranylgeranyl cysteine (By  

Keyword

 Complete proteome; Cytoplasm; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
 GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.
 GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.
 GO:0061097; P:regulation of protein tyrosine kinase activity; ISS:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.