UniProt Accession

 TIM22_HUMAN; Q9Y584; Q9NWI8 

Genbank Protein ID

 AF155330; AK000830; BC002324 

Genbank Nucleotide ID

 AAD40106.1; BAA91392.1; AAH02324.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim22 

Protein Synonyms/Alias

 Testis-expressed sequence 4 

Gene Name

 TIMM22 

Gene Synonyms/Alias

 TEX4; TIM22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	GGIPSPAKSEEQKMI	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:BHF-UCL.
 GO:0015266; F:protein channel activity; TAS:BHF-UCL.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0045039; P:protein import into mitochondrial inner membrane; TAS:BHF-UCL. 

Interpro

 IPR003397; Tim17/Tim22/Tim23/PMP24. 

Pfam

 PF02466; Tim17 

SMART

  

PROSITE

  

PRINTS