CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SLIT and NTRK-like protein 4 
Protein Synonyms/Alias
  
Gene Name
 SLITRK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
718FSDPPGQKVVMRNVAubiquitination[1]
766IQNFLESKKEYNSIGubiquitination[1]
792QPDKKSKKSLIGGNHmethylation[2]
801LIGGNHSKIVVEQRKmethylation[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Suppresses neurite outgrowth (By similarity). 
Sequence Annotation
 REPEAT 60 81 LRR 1.
 REPEAT 84 105 LRR 2.
 REPEAT 108 129 LRR 3.
 REPEAT 132 153 LRR 4.
 REPEAT 156 177 LRR 5.
 REPEAT 179 200 LRR 6.
 DOMAIN 213 264 LRRCT 1.
 DOMAIN 333 375 LRRNT.
 REPEAT 378 399 LRR 7.
 REPEAT 402 423 LRR 8.
 REPEAT 426 447 LRR 9.
 REPEAT 450 471 LRR 10.
 REPEAT 474 495 LRR 11.
 REPEAT 497 518 LRR 12.
 DOMAIN 531 582 LRRCT 2.
 CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
 CARBOHYD 325 325 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN 60
FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG GAFLGLSALK QLHLNNNELK 120
ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL 180
THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA 240
ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV 300
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDLGLSVN 360
CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF EGLDLLHLGS NQITVIKGDV 420
FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEISAGTFD SMPNLQLLYL 480
NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV 540
ALKLWVEKLS DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF 600
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNPD 660
CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVV 720
MRNVADKEKD LLHVDTRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR 780
YPEKQPDKKS KKSLIGGNHS KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI 837 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007409; P:axonogenesis; IEA:Compara. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
  
SMART
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS