UniProt Accession

 DCTN2_RAT; Q6AYH5 

Genbank Protein ID

 BC079042 

Genbank Nucleotide ID

 AAH79042.1 

Protein Name

 Dynactin subunit 2 

Protein Synonyms/Alias

  

Gene Name

 Dctn2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MADPKYADLPGI	ubiquitination	[1]
146	AKQLAALKQQLVASH	acetylation	[2]
309	EDADTQNKVHQLYET	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 6 6 Phosphotyrosine (By similarity).
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 86 86 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Membrane; Microtubule; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 402 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:RGD.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005869; C:dynactin complex; IDA:RGD.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0000776; C:kinetochore; IDA:RGD.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0031982; C:vesicle; ISS:UniProtKB.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0007067; P:mitosis; IDA:RGD.
 GO:0007052; P:mitotic spindle organization; IDA:RGD. 

Interpro

 IPR006996; Dynamitin_2su. 

Pfam

  

SMART

  

PROSITE

  

PRINTS