CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011570
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar protein 12 
Protein Synonyms/Alias
  
Gene Name
 NOP12 
Gene Synonyms/Alias
 YOL041C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
23KIESSVDKLFSSSCGacetylation[1]
34SSCGPINKLEVKSKTacetylation[1]
104LEARYYAKLLNEEAEacetylation[1]
116EAEAEDDKPTVTKTDacetylation[1]
121DDKPTVTKTDETSVPacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in pre-25S rRNA processing. 
Sequence Annotation
 DOMAIN 279 371 RRM.
 MOD_RES 70 70 Phosphoserine.
 MOD_RES 181 181 Phosphothreonine.
 MOD_RES 184 184 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MSSAIDNLFG NIDEKKIESS VDKLFSSSCG PINKLEVKSK TRTVLPDSKK RERAAEADQE 60
EKEASKPDVS DEQTEEVALP KVKKAKKSKR NDEDEDLEAR YYAKLLNEEA EAEDDKPTVT 120
KTDETSVPLT SAAKKVDFKE DELEKAERTV FIGNILSTVI TSKKVYKEFK KLFGTNPIAE 180
TEESGNEKEE ESSKKSDNNE FAIESIRFRS ISFDEALPRK VAFVQQKFHK SRDTINAYIV 240
YKNKSAVRKI CSNLNAVVFQ DHHLRVDSVA HPAPHDKKRS IFVGNLDFEE IEESLWKHFE 300
PCGDIEYVRI IRDSKTNMGK GFAYVQFKDL QSVNKALLLN EKPMKSQKQE DENTKKPTKK 360
ARKLRVSRCK NMKKGTTIGT GLDRNGLTDS QRTRAGRAKK ILGKADRATL GQEITIEGLR 420
AKKGEGSTHL KKKKQRSATG RVTKRSIAFK KAQAEKSKK 459 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0030684; C:preribosome; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:SGD.
 GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS