CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021828
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LIM domain-binding protein 3 
Protein Synonyms/Alias
 Protein cypher; Protein oracle; Z-band alternatively spliced PDZ-motif protein 
Gene Name
 Ldb3 
Gene Synonyms/Alias
 Kiaa0613 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
181AQGSVSPKVLPGPSQubiquitination[1]
218YQMSLRGKASGAGLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. 
Sequence Annotation
 DOMAIN 1 84 PDZ.
 DOMAIN 545 603 LIM zinc-binding 1.
 DOMAIN 604 663 LIM zinc-binding 2.
 DOMAIN 664 723 LIM zinc-binding 3.  
Keyword
 3D-structure; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 723 AA 
Protein Sequence
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM 60
THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPIQSPL PVIPHQKDPA LDTNGSLATP 120
SPSPEARASP GALEFGDTFS SSFSQTSVCS PLMEASGPVL PLGSPVAKAS SEGAQGSVSP 180
KVLPGPSQPR QYNNPIGLYS AETLREMAQM YQMSLRGKAS GAGLLGGSLP VKDLAVDSAS 240
PVYQAVIKTQ SKPEDEADEW ARRSSNLQSR SFRILAQMTG TEYMQDPDEE ALRRSRPQAS 300
AYSPAAAASP APSAHTSYSE GPAAPAPKPR VVTTASIRPS VYQPVPASSY SPSPGANYSP 360
TPYTPSPAPA YTPSPAPTYT PSPAPTYSPS PAPAYTPSPA PNYTPTPSAA YSGGPSESAS 420
RPPWVTDDSF SQKFAPGKST TTVSKQTLPR GAPAYNPTGP QVTPLARGTF QRAERFPASS 480
RTPLCGHCNN VIRGPFLVAM GRSWHPEEFN CAYCKTSLAD VCFVEEQNNV YCERCYEQFF 540
APICAKCNTK IMGEVMHALR QTWHTTCFVC AACKKPFGNS LFHMEDGEPY CEKDYINLFS 600
TKCHGCDFPV EAGDKFIEAL GHTWHDTCFI CAVCHVNLEG QPFYSKKDKP LCKKHAHAIN 660
V 661 
Gene Ontology
 GO:0005856; C:cytoskeleton; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0051371; F:muscle alpha-actinin binding; IDA:MGI.
 GO:0005080; F:protein kinase C binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045214; P:sarcomere organization; IMP:MGI. 
Interpro
 IPR001478; PDZ.
 IPR006643; ZASP.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF00595; PDZ 
SMART
 SM00132; LIM
 SM00228; PDZ
 SM00735; ZM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50106; PDZ 
PRINTS