CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldehyde dehydrogenase, cytosolic 1 
Protein Synonyms/Alias
 ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A7; Aldehyde dehydrogenase phenobarbital-inducible 
Gene Name
 Aldh1a7 
Gene Synonyms/Alias
 Aldh-pb 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
17PAPLANLKIQHTKIFubiquitination[1]
36WHDSVSSKKFPVLNPubiquitination[1]
57CHVEEGDKADVDKAVacetylation[2]
62GDKADVDKAVKAARQacetylation[2]
62GDKADVDKAVKAARQubiquitination[1]
91ERGRLLNKLADLMERacetylation[2]
91ERGRLLNKLADLMERubiquitination[1]
252TGSTEVGKLIKEAAGubiquitination[1]
255TEVGKLIKEAAGKSNubiquitination[1]
329RSVERAKKYILGNPLubiquitination[1]
348NQGPQIDKEQHNKILubiquitination[1]
353IDKEQHNKILGLIESubiquitination[1]
362LGLIESGKKEGAKLEubiquitination[1]
363GLIESGKKEGAKLECubiquitination[1]
378GGGRWGNKGFFVQPTubiquitination[1]
398TDEMRIAKEEIFGPVubiquitination[1]
410GPVQQIMKFKSMDDVacetylation[2]
410GPVQQIMKFKSMDDVubiquitination[1]
412VQQIMKFKSMDDVIKubiquitination[1]
419KSMDDVIKRANNTTYubiquitination[1]
435LAAGVFTKDLDKAITubiquitination[1]
490LYEYTELKTVAMQISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
 Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal. 
Sequence Annotation
 NP_BIND 246 251 NAD (By similarity).
 ACT_SITE 269 269 Proton acceptor (By similarity).
 ACT_SITE 303 303 Nucleophile (By similarity).  
Keyword
 Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC HVEEGDKADV 60
DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMESMN AGKVFAHAYL 120
LDVEISIKAL QYFAGWADKI HGQTIPSDGN IFTYTRREPI GVCGQIIPWN GPLIIFTWKL 180
GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID 240
KVSFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 300
QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ HNKILGLIES 360
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSMDDVIKR 420
ANNTTYGLAA GVFTKDLDKA ITVSSALQAG MVWVNCYLAV PVQCPFGGFK MSGNGRELGE 480
HGLYEYTELK TVAMQISQKN S 501 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
 GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS