| Tag | Content |
|---|
| CPLM ID | CPLM-015559 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase UBR3 |
Protein Synonyms/Alias | N-recognin-3; Ubiquitin-protein ligase E3-alpha-3; Ubiquitin-protein ligase E3-alpha-III; Zinc finger protein 650 |
Gene Name | UBR3 |
Gene Synonyms/Alias | KIAA2024; ZNF650 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1045 | LVAERRKKFQEIINR | ubiquitination | [1] | | 1141 | AVERILLKAASQSRM | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). |
Sequence Annotation | ZN_FING 118 189 UBR-type.
ZN_FING 1306 1364 RING-type; degenerate. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Ligase; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1888 AA |
Protein Sequence | MAAAAAAAVG GQQPSQPELP APGLALDKAA TAAHLKAALS RPDNRAGAEE LQALLERVLS 60
AERPLAAAAG GEDAAAAGGG GGPGAAEEEA LEWCKCLLAG GGGYDEFCAA VRAYDPAALC 120
GLVWTANFVA YRCRTCGISP CMSLCAECFH QGDHTGHDFN MFRSQAGGAC DCGDSNVMRE 180
SGFCKRHQIK SSSNIPCVPK DLLMMSEFVL PRFIFCLIQY LREGYNEPAA DGPSEKDLNK 240
VLQLLEPQIS FLEDLTKMGG AMRSVLTQVL TNQQNYKDLT SGLGENACVK KSHEKYLIAL 300
KSSGLTYPED KLVYGVQEPS AGTSSLAVQG FIGATGTLGQ VDSSDEDDQD GSQGLGKRKR 360
VKLSSGTKDQ SIMDVLKHKS FLEELLFWTI KYEFPQKMVT FLLNMLPDQE YKVAFTKTFV 420
QHYAFIMKTL KKSHESDTMS NRIVHISVQL FSNEELARQV TEECQLLDIM VTVLLYMMES 480
CLIKSELQDE ENSLHVVVNC GEALLKNNTY WPLVSDFINI LSHQSVAKRF LEDHGLLVTW 540
MNFVSFFQGM NLNKRELNEH VEFESQTYYA AFAAELEACA QPMWGLLSHC KVRETQEYTR 600
NVVRYCLEAL QDWFDAINFV DEPAPNQVTF HLPLHRYYAM FLSKAVKCQE LDLDSVLPDQ 660
EMLMKLMIHP LQIQASLAEI HSNMWVRNGL QIKGQAMTYV QSHFCNSMID PDIYLLQVCA 720
SRLDPDYFIS SVFERFKVVD LLTMASQHQN TVLDAEHERS MLEGALTFLV ILLSLRLHLG 780
MSDDEILRAE MVAQLCMNDR THSSLLDLIP ENPNPKSGII PGSYSFESVL SAVADFKAPV 840
FEPGGSMQQG MYTPKAEVWD QEFDPVMVIL RTVYRRDVQS AMDRYTAFLK QSGKFPGNPW 900
PPYKKRTSLH PSYKGLMRLL HCKTLHIVLF TLLYKILMDH QNLSEHVLCM VLYLIELGLE 960
NSAEEESDEE ASVGGPERCH DSWFPGSNLV SNMRHFINYV RVRVPETAPE VKRDSPASTS 1020
SDNLGSLQNS GTAQVFSLVA ERRKKFQEII NRSSSEANQV VRPKTSSKWS APGSAPQLTT 1080
AILEIKESIL SLLIKLHHKL SGKQNSYYPP WLDDIEILIQ PEIPKYSHGD GITAVERILL 1140
KAASQSRMNK RIIEEICRKV TPPVPPKKVT AAEKKTLDKE ERRQKARERQ QKLLAEFASR 1200
QKSFMETAMD VDSPENDIPM EITTAEPQVS EAVYDCVICG QSGPSSEDRP TGLVVLLQAS 1260
SVLGQCRDNV EPKKLPISEE EQIYPWDTCA AVHDVRLSLL QRYFKDSSCL LAVSIGWEGG 1320
VYVQTCGHTL HIDCHKSYME SLRNDQVLQG FSVDKGEFTC PLCRQFANSV LPCYPGSNVE 1380
NNPWQRPSNK SIQDLIKEVE ELQGRPGAFP SETNLSKEME SVMKDIKNTT QKKYRDYSKT 1440
PGSPDNDFLF MYSVARTNLE LELIHRGGNL CSGGASTAGK RSCLNFCFII SPFTKSEIIL 1500
CQYRKSHDKV YPKYQLFHVL ALHMRLYSID SEYNPWRKLT QLEEMNPQLG YEEQQPEVPI 1560
LYHDVTSLLL IQILMMPQPL RKDHFTCIVK VLFTLLYTQA LAALSVKCSE EDRSAWKHAG 1620
ALKKSTCDAE KSYEVLLSFV ISELFKGKLY HEEGTQECAM VNPIAWSPES MEKCLQDFCL 1680
PFLRITSLLQ HHLFGEDLPS CQEEEEFSVL ASCLGLLPTF YQTEHPFISA SCLDWPVPAF 1740
DIITQWCFEI KSFTERHAEQ GKALLIQESK WKLPHLLQLP ENYNTIFQYY HRKTCSVCTK 1800
VPKDPAVCLV CGTFVCLKGL CCKQQSYCEC VLHSQNCGAG TGIFLLINAS VIIIIRGHRF 1860
CLWGSVYLDA HGEEDRDLRR GKPLYICKER YKVLEQQWIS HTFDHINKRW GPHYNGL 1917 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0009790; P:embryo development; ISS:UniProtKB. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0042048; P:olfactory behavior; IEA:Compara. GO:0007608; P:sensory perception of smell; ISS:UniProtKB. GO:0001967; P:suckling behavior; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |