CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041771
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibrillin 1, isoform CRA_a 
Protein Synonyms/Alias
 Protein Fbn1 
Gene Name
 Fbn1 
Gene Synonyms/Alias
 rCG_27283 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
800CPKGFVYKPDLKTCEacetylation[1]
1018RGPGFATKDITNGKPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2872 AA 
Protein Sequence
MRRGGLLEVA LAFTLLLESY TSHGADANLE AGSLKETRAN RAKRRGGGGH DALKGPNVCG 60
SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC TCPSGQISPS CGSRSIQHCS 120
IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC ESGCLNGGRC VAPNRCACTY GFTGPQCERD 180
YRTGPCFTVV SNQMCQGQLS GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR 240
TGACQDVDEC QAIPGLCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGVCD 300
GGECTNTVSS YFCKCPPGFY TSPDGTRCVD VRPGYCYTTL TNGRCSNQLP QSITKMQCCC 360
DVGRCWSPGV TVAPEMCPIR STEDFNKLCS VPLVIPGRPD YPPPPLGPLP PVQPVPGFPS 420
GPVIPVPRPP PEYPYPSPSR EPPKVLPFNV TDYCQLVRYL CQNGRCIPTP GSYRCECNKG 480
FQLDIRGECI DVDECEKNPC TGGECINNQG SYTCHCRAGY QSTLTRTECR DIDECLQNGR 540
ICNNGRCINT DGSFHCVCNA GFHVTRDGKN CEDMDECSIR NMCLNGMCIN EDGSFKCICK 600
PGFQLASDGR YCKDINECET PGICMNGRCV NTDGSYRCEC FPGLAVGLDG RVCVDTHMRS 660
TCYGGYRRGQ CVKPLFGAVT KSECCCASTE YAFGEPCQPC PAQNSAEYQA LCSSGPGMTS 720
AGSDINECAL DPDICPNGIC ENLRGTYKCI CNSGYEVDIT GKNCVDINEC VLNSLLCDNG 780
QCRNTPGSFV CTCPKGFVYK PDLKTCEDID ECESSPCING VCKNSPGSFI CECSPESTLD 840
PTKTICIETI KGTCWQTVID GRCEININGA TLKSECCSSL GAAWGSPCTI CQVDPICGKG 900
YSRIKGTQCE DINECEVFPG VCKNGLCVNS RGSFKCECPS GMTLDATGRI CLDIRLETCF 960
LKYDDEECTL PIAGRHRMDA CCCSVGAAWG TEECEECPLR NSREYEELCP RGPGFATKDI 1020
TNGKPFFKDI NECKMIPSLC THGKCRNTIG SFKCRCDSGF ALDSEERNCT DIDECRISPD 1080
LCGRGQCVNT PGDFECKCDE GYESGFMMMK NCMDIDECQR DPLLCRGGIC HNTEGSYRCE 1140
CPSGHQLSPN ISACIDINEC ELSANLCPSG RCVNLIGKYQ CACNPGYHPT HDRLFCVDID 1200
ECSIMNGGCE TFCTNSDGSY ECSCQPGFAL MPDQRSCTDI DECEDNPNIC DGGQCTNIPG 1260
EYRCLCYDGF MASEDMKTCV DVNECDLNPN ICLSGTCENT KGSFICHCDM GYSGKKGKTG 1320
CTDINECEIG AHNCGRHAVC TNTAGSFKCS CSPGWIGDGI KCTDLDECSN GTHMCSQHAD 1380
CKNTMGSYRC LCKDGYTGDG FTCTDLDECS ENLNLCGNGQ CLNAPGGYRC ECDMGFVPSA 1440
DGKACEDINE CSLPNICVFG TCHNLPGLFR CECEIGYELD RSGGNCTDVN ECLDPTTCIS 1500
GNCVNTPGSY TCDCPPDFEL NPTRVGCVDT RSGNCYLDIR PRGDNGDTAC SNEIGVGVSK 1560
ASCCCSLGKA WGTPCELCPP VNTSEYKILC PGGEGFRPNP ITVILEDIDE CQELPGLCQG 1620
GKCINTFGSF QCRCPTGYYL NEDTRVCDDV NECETPGICG PGTCYNTVGN YTCICPPDYM 1680
QVNGGNNCMD MRRSLCYRNY HADNQTCDGE LLFNMTKKMC CCSYNIGRAW NKPCEQCPIP 1740
STDEFATLCG SQRPGFVIDI YTGLPVDIDE CREIPGVCEN GVCINMVGSF RCECPVGFFY 1800
NDKLLVCEDI DECQNGPVCQ RNAECINTAG SYRCDCKPGY RLTSTGQCND RNECQEIPNI 1860
CSHGQCIDTV GSFYCLCHTG FKTNADQTMC LDINECERDA CGNGTCRNTI GSFNCRCNHG 1920
FILSHNNDCI DVDECATGNG NLCRNGQCVN TVGSFQCRCN EGYEVAPDGR TCVDINECVL 1980
DPGKCAPGTC QNLDGSYRCI CPPGYSLQND KCEDIDECVE EPEICALGTC SNTEGSFKCL 2040
CPEGFSLSST GRRCQDLRMS YCYAKFEGGK CSSPKSRNHS KQECCCALKG EGWGDPCELC 2100
PTEPDEAFRQ ICPFGSGIIV GPDDSAVDMD ECKEPDVCKH GQCINTDGSY RCECPFGYIL 2160
EGNECVDTDE CSVGNPCGNG TCKNVIGGFE CTCEEGFEPG PMMTCEDINE CAQNPLLCAF 2220
RCVNTYGSYE CKCPVGYVLR EDRRMCKDED ECAEGKHDCT EKQMECKNLI GTYMCICGPG 2280
YQRRPDGEGC IDENECQTKP GICENGRCLN TLGSYTCECN DGFTASPTQD ECLDNREGYC 2340
FSEVLQNMCQ IGSSNRNPVT KSECCCDGGR GWGPHCEICP FEGTVAYKKL CPHGRGFMTN 2400
GADIDECKVI HDVCRNGECV NDRGSYHCIC KTGYTPDITG TACVDLNECN QAPKPCNFIC 2460
KNTEGSYQCS CPKGYILQED GRSCKDLDEC ATKQHNCQFL CVNTIGGFTC KCPPGFTQHH 2520
TACIDNNECT SEINLCGSKG VCQNTPGSFT CECQRGFSLD QSGASCEDVD ECEGNHRCQH 2580
GCQNIIGGYR CSCPQGYLQH YQWNQCVDEN ECLSAHVCGG ASCHNTLGSY KCMCPAGFQY 2640
EQFSGGCQDI NECGSSQAPC SYGCSNTEGG YLCGCPPGYL RIGQGHCVSG MGMGRGGPEP 2700
PASGEMDDNS LSPEACYECK INGYPKRGRK RRSTNETDAS DIQDGSEMEA NVSLASWDVE 2760
KPASFAFNIS HINNKVRILE LLPALTTLMN HNKYLIESGN EDGFFKINQK EGVSYLHFTK 2820
KKPVAGTYSL QISSTPLYKK KELNQLEDRY DKDYLSGELG DNLKMKIQIL LH 2872 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0031012; C:extracellular matrix; IDA:RGD.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0001527; C:microfibril; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005201; F:extracellular matrix structural constituent; IMP:RGD.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0001822; P:kidney development; IMP:RGD.
 GO:0001501; P:skeletal system development; IEA:Compara. 
Interpro
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR011398; FBN.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR017878; TB_dom. 
Pfam
 PF12662; cEGF
 PF07645; EGF_CA
 PF00683; TB 
SMART
 SM00181; EGF
 SM00179; EGF_CA 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS51364; TB 
PRINTS