CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010038
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Putative type I restriction enzyme specificity protein MPN_638 
Protein Synonyms/Alias
 S protein 
Gene Name
 MPN_638; E30_orf375, MP204 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
4****MTPKLKLNTNSacetylation[1]
25LGSLFELKKGEMLEKacetylation[1]
40ELLAPDGKYEYFNGGacetylation[1]
133NIRLSDLKDLPIPLVacetylation[1]
141DLPIPLVKSIQDQRTacetylation[1]
216VFHLKSGKYLKADERacetylation[1]
228DERFEDGKFPYYGAGacetylation[1]
284GIAMEALKPNKTYVPacetylation[1]
309KDLKERFKRDESPFIacetylation[1]
325LKLAGEIKVPFVKSFacetylation[1]
330EIKVPFVKSFALQRKacetylation[1]
340ALQRKAGKIIYLLDKacetylation[1]
347KIIYLLDKTLEECKEacetylation[1]
353DKTLEECKEEAKSLIacetylation[1]
369IRDNLLGKLFPTLS*acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Reference proteome; Restriction system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MTPKLKLNTN SNWTKKTLGS LFELKKGEML EKELLAPDGK YEYFNGGIKA SGRTNEFNTF 60
KNTISIIIGG SCGYVRLADK DYFCGQSSCT LTVLDPLEID LKFAYYALKS QEEKITSLAS 120
GTTIKNIRLS DLKDLPIPLV KSIQDQRTIA HALSVFDLRI EHLNELIEVN RKLRDEYAHK 180
LFTLDPDFLT HWNLHELHEQ MGEISLGEVF HLKSGKYLKA DERFEDGKFP YYGAGIESTS 240
FVNEPNTKGD TLSMIANGYS IGNIRYHTIP WFNGTGGIAM EALKPNKTYV PFFYCALKYM 300
QKDLKERFKR DESPFISLKL AGEIKVPFVK SFALQRKAGK IIYLLDKTLE ECKEEAKSLI 360
SIRDNLLGKL FPTLS 375 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW. 
Interpro
 IPR000055; Restrct_endonuc_typeI_HsdS. 
Pfam
 PF01420; Methylase_S 
SMART
  
PROSITE
  
PRINTS