UniProt Accession

 CEBPE_HUMAN; Q15744; Q15745; Q8IYI2; Q99803 

Genbank Protein ID

 U48865; U48866; U80982; BC035797 

Genbank Nucleotide ID

 AAC50708.1; AAC50709.1; AAC51130.1; AAH35797.2 

Protein Name

 CCAAT/enhancer-binding protein epsilon 

Protein Synonyms/Alias

 C/EBP epsilon 

Gene Name

 CEBPE 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
121	DPRAVAVKEEPRGPE	sumoylation	[1, 2]

Reference

 [1] Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
 Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC.
 J Biol Chem. 2002 Oct 11;277(41):38037-44. [PMID: 12161447]
 [2] Repression and coactivation of CCAAT/enhancer-binding protein epsilon by sumoylation and protein inhibitor of activated STATx proteins.
 Kim J, Sharma S, Li Y, Cobos E, Palvimo JJ, Williams SC.
 J Biol Chem. 2005 Apr 1;280(13):12246-54. [PMID: 15661739] 

Functional Description

 C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. 

Sequence Annotation

 DOMAIN 204 267 bZIP.
 REGION 208 228 Basic motif (By similarity).
 REGION 230 237 Leucine-zipper (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0042089; P:cytokine biosynthetic process; IEA:Compara.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0042742; P:defense response to bacterium; IEA:Compara.
 GO:0030225; P:macrophage differentiation; IEA:Compara.
 GO:0006909; P:phagocytosis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS