CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BRO1 domain-containing protein BROX 
Protein Synonyms/Alias
 C1orf58 protein; cDNA, FLJ78829 
Gene Name
 C1orf58 
Gene Synonyms/Alias
 BROX 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116KEVHRSLKIAAGIFKubiquitination[1]
123KIAAGIFKHLKESHLubiquitination[2]
126AGIFKHLKESHLPKLubiquitination[1]
171IARAIELKHAPGLIAubiquitination[3]
302NGFIYFQKIPTEAPQubiquitination[2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MTHWFHRNPL KATAPVSFNY YGVVTGPSAS KICNDLRSSR ARLLELFTDL SCNPEMMKNA 60
ADSYFSLLQG FINSLDESTQ ESKLRYIQNF KWTDTLQGQV PSITEDEAKE VHRSLKIAAG 120
IFKHLKESHL PKLITPAEKG RDLESRLIEA YVIQCQAEAQ EVTIARAIEL KHAPGLIAAL 180
AYETANFYQK ADHTLSSLEP AYSAKWRKYL HLKMCFYTAY AYCYHGETLL ASDKCGEAIR 240
SLQEAEKLYA KAEALCKEYG ETKGPGPTVK PSGHLFFRKL GNLVKNTLEK CQRENGFIYF 300
QKIPTEAPQL ELKANYGLVE PIPFEFPPTS VQWTPETLAA FDLTKRPKDD STKPKPEEEV 360
KPVKEPDIKP QKDTGCYIS 379 
Gene Ontology
  
Interpro
 IPR004328; BRO1_dom. 
Pfam
 PF03097; BRO1 
SMART
 SM01041; BRO1 
PROSITE
 PS51180; BRO1 
PRINTS