CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027068
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain at 62B 
Protein Synonyms/Alias
  
Gene Name
 Dhc62B 
Gene Synonyms/Alias
 CG15804; Dmel_CG15804 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1625WTDGLVAKIFRDFAMacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3964 AA 
Protein Sequence
MYTKKLERMH RPASDITKYD NEPYMKNPLL KFRISEVHER RHYQFLKQKA ADVKVRVARQ 60
QWQPEPDMRL LPQSHYEDNL RREVRKIVVP PMLRRTEAKI LSFASERLKN KYPELVQAYM 120
HDVHEEFNRL MKVYSMKNIL RHPEFSDEDP AQFELPRPDI GFRRPGRTQN YSNFLENRRR 180
IAQKLLILQL PLRAILNISV GELPKLACIF NYVLATGAMQ QQLGLGGREA LSYKFYHKYI 240
QNQLDKVNTF LRWTWYPKIV QVLRKLMRKR VMPMSTWKRS WNAMEALMNR EMTNMKIRTF 300
EEMYRMCSHP RTMPMMRMSL EWSEFSSDLD TRPNAWSILR TFAEIATEIS MVGYRMEPLQ 360
PQVQTLTSMA AYAKVNDYLK IEMNDNFLKD VIDKVQNIIL RTYQEVIQYV EGFRDKYYAL 420
YSWQERDALN QFLSEPHEFE EYFARIDMYY GFIQMLRSEP ATEYFVMAVI HNEPAIFGLR 480
TLAENLIHEI TTIIIREHIK AEVDICDEFE KIKYRALEIP KSTEELLESA EYMIHVKKDK 540
IAELTDRIQY CLQVGTNIVE LTEMSKYHFD LTIKTINWIK DINDICDYNA SQQEQFKFTF 600
EEHLQEVIKK LNSDIDELLP KLTVIDDMSR PDKFRDSYII LQNFIDQLKT FDDYVAWINK 660
EEKLFKVALT EYPKLDIIKT FVYPFAELMK CCIEWQRYLS VWNDGPFEYL EPQFVERTTD 720
DYLKEFQKNQ KYYRVKIKQD LIDNPVCKFK GQTEDPDPAK HPVPLRLCTS MIQSIKDFTT 780
GVFIVNTMCN PALRKRHWKE MSEIAGFDVT PDAGTTLRKI LNSGLDPILD QFEIISIGAN 840
KELQLWNALQ AMIKEWETRV FPYGPYKETG VQILSSLDDI QALLDDHILK TLVMRGSAFM 900
KPCEEEVRAW YEKIMRVNET LDQWGKVQAN YLYLLPIFSS KDIVAQMPEE GRLFVIVEQT 960
YTRNMGLVLR QPLVMETAPV SGLLESLQKA NELLEDIATG VSNYLEKKRL YFPRFFFLAN 1020
DEMLEILSET KDPLRVLPHL SKCFEGINSL EFDAAKNVLA MISSDKETIE FIEQVSTAAA 1080
GGSVEKWLIG VEDEMLKAVR YQNELSFAHY PKVKRHEWVL EWPQMTVLAI SQVYWASRVH 1140
GCLRRTFGGN MTIMMNFFQE LSKELNDIVT LVRSPKISNL NRITIKSLIV IDVHAKDVSE 1200
DLIKNKVSSE FDFQWLAQMR YYWEDDKTWV RIINATVPFA NEYLGNSDRL VITPLTDRCY 1260
RTLVGAYQLH LNGAPEGPAG TGKTETTKDL AKALAVQCKV FNCSDGLDYK AMGKFFKGLA 1320
SCGAWACFDE FNRIELEVLS VVAQQILLII QAVRSNATKF MFEGTELTLN PACYVCITMN 1380
PGYAGRSELP DNLKVLFRSV AMMVPDYAMI GEISLYSYGF VDARKLAVKI VTTYRLCSEQ 1440
LSSQNHYDYG MRAVKTVLSA CGNIKKQYPD EVEDILLLRS LIDVNLPKFL SFDVPLFEGI 1500
ISDIFPGIKL PHIDYSLVES EFKRVCLEEV LEPAPSFLLK VIQTYEMIIV RHGFMLVGEP 1560
LAGKSKTLQV LAKVLSALKI KAPQKSNYFQ HVQMGIMNPK SITMNQLYGS FDPISYEWTD 1620
GLVAKIFRDF AMTPTPDRKW VIFDGPVDAV WIENMNTVLD DNKKLCLTSG EVITMSNEMS 1680
MVFEVMDLAQ ASPATVSRCG MIYMEPSTLG WRAFAKSWLK KADPRWADEE GVPYVMALMQ 1740
WLLPPCQTFV RRFCSQFIKP GEFNCMLTTF DLFDMQIAEA IEENPEDYQK YLQTYFQAAI 1800
LFALIWGVGG VLDTASREKF DVFLKKLWDT DPPPPEPLGK MEITPPTEGL LVDYVFLYKQ 1860
RGAWRYWPDL AKRMDVEETK TGVIVPTVDT ARYIHLLKMH VEHKKRMLLV GPTGTGKTVY 1920
VQNYLMNKLD KEVFETGFIT FTVMISANQC QDLLISKLQK WKRGIYGPPK GMQSVLFVDD 1980
MNMPVKEVYG AQPPLELLRQ FFDYGHVYDL KDSSKVYIHN VLIMAACGLP GGSRQDVYAR 2040
FLNHFNVYSI NTFSDDSMFR IFLNVALNGF RRAGHGQDVF VVTNQIVSAT QSIYKSVQSE 2100
IRATPSKSHY IFNLRDISRV VTGCTLVRKE SVSDKKIFVR VWYHEAMRVF YDRLVDDVDR 2160
KWMFDKLNEC LKANFKDKVE TVFERYCVQG PDEAVFTMEA ASNILFGVYF DEDSVPDERR 2220
YEEVPSVEVF LNLALTSLDD YNSTRRNKMD ITLFTFALQH LNRICRIISI QGASALIIGL 2280
GGSGRQSLTK LATNMVQTSF FQPEITKNYG ANDWHDDIKA ILKEAGGMNK HTTFLITENQ 2340
IKMELFLQDI DCLLNQGEVP NIFPIDEKQE VLEMVRLAAQ GGNRNIDVSA LQVFSFFVDR 2400
CKQKLHMILS FSPIGDALRT RVRLYPSLVN CCTIDWYDSW PEEALQMIAK MSLVDVNVPS 2460
EDIKLAIMDT CQYFHTTAAR STRAFCQMTG RHIYQTNASF IELIRSFQTL IERKQSETML 2520
AKMRYIGGLD TLAQAAAAIS IMQRDLNALQ PKLVALAESS RKMMLEINKE TLAASAAAEQ 2580
VKRDEEVASV QAEAAQVLKQ DCERDLAKAI PVLEDALAAL NTLKPADITL VKSMKNPPPV 2640
IKLVMAAVCV IKGIPPERIP DPASGKMVQD YWGPSKRLLG EMNFLPGLKE FDKDNIPTEI 2700
VKRIHKEFIP NKDFDPKVVA KASSAAKGLC QWIIAMMMYD EVAKVVAPKK AKLAGAEKEY 2760
ADTMEFLAQK RALALALEEK VALLNIELDK ANAEMQKTEE HAESCRNKLL RAEALIGGLG 2820
GEKSRWNKAA EDLQELYDHL PGDVLISCGI IAYLSAVNLQ YRSECVKDWF KKVTDLKIPC 2880
SSHYSITDVL GLEVTIQNWQ LDGLPNDEFS SENAIISANS SRYSLFIDPQ AQANNWLKNM 2940
ERKNRLNCVK FNQSNYMKVI AEALEYGTPV IIENVQEELE VPLDPILMRQ TFVQGGIKHI 3000
SLGESVVPVN PNFRLYMTCN LRNPHFLPET FNKVTVINFA LTQNALMDQL LSIVVAKERP 3060
DLQELRITLT TEAAANKGAL RDAENMILKT LSAGGDILEN EAAIQILADS KGLSKDIVEK 3120
QEAAKETVAK IEAFRLNYKP VAVHSSILYY SITDLPNIDP MYQFSLNWYI NLYMYSIETA 3180
NKSKDLPRRI KFLVDGFTRN LYNNVCRSIF EKDKLLYSFI LTARILLGTG QVEMRHFAHL 3240
VTNAKESTNI PPNPDPTWIT ETVWLNVLRL EELKELRGIV DHFKSHLHAW QAIYDHSSPE 3300
KQPLPPPWQD KTTAFEKIIV LKALRPDSVF LAVRLFIAES IGDQYVTPPE FDISKSYADS 3360
TALTPLVFIL SPGADPLGSL LAFAEKMGQE ETFQSISLGQ GQGPIATALI KNAQEMGYWV 3420
CLQNCHLAAS WMPYLEYLWE NMDTFNTTPN FRIWLTAYPT PQFPVTILQN GVKMTNEPPT 3480
GLKENLMRSY NSEPINDYEF YTGCAKQDRA FTRLLYGICF FHAVVQERRK YGPLGWNIAY 3540
GFNESDLQIS VLQLSMLLNQ YDHVPYDAIS YLTSECNYGG RVTDNWDRRL IVTILADFCN 3600
AQAVTDNRYR FASDDRYILP RKTEHREILR YLDENLPSLA PPEVYGLHAN SGITRDLQTT 3660
KTLLDSMILL LGSEAAGSAG AGVSVEQVIL DTIKQIEREM PADMDIEAAA EKYPVDYNES 3720
MNTVVVQEME RFLKLQKEIR TTCRDLAMGI KGIIVMTPDL ENVMTAMKFN RIPTKWMSKS 3780
YPCLKPLGSY VQDLYKRLNW LHDWHHHGKP PTFWLSGFFF TQAFLTGAMQ NFARKYKIPI 3840
DTLTFDYDVL KVETKTSPPD DGVYCNGLYL EGARWEWREN TLVEQFPKVL IYAMPVIFFR 3900
PVGLVDVVEG SRYRCPLYKT AERKGTLSTT GHSTNYVVPL LLNTHVKASH WVKRSVALIC 3960
QTSD 3964 
Gene Ontology
 GO:0030286; C:dynein complex; IEA:InterPro.
 GO:0005875; C:microtubule associated complex; ISS:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042623; F:ATPase activity, coupled; ISS:FlyBase.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; ISS:FlyBase.
 GO:2001019; P:positive regulation of retrograde axon cargo transport; IMP:FlyBase. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026983; DHC_fam.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF12780; AAA_8
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS