UniProt Accession

 TYB10_RAT; P63312; P13472 

Genbank Protein ID

 M17698; M58404; M58405 

Genbank Nucleotide ID

 AAA42244.1; AAA42247.1; AAA42248.1 

Protein Name

 Thymosin beta-10 

Protein Synonyms/Alias

  

Gene Name

 Tmsb10 

Gene Synonyms/Alias

 Ptmb10; Thyb10 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MADKPDMGEIA	acetylation	[1]
15	GEIASFDKAKLKKTE	acetylation	[1]
26	KKTETQEKNTLPTKE	acetylation	[1]
32	EKNTLPTKETIEQEK	acetylation	[1]
39	KETIEQEKRSEIS**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 4 4 N6-acetyllysine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 23 23 Phosphothreonine (By similarity).
 MOD_RES 39 39 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 44 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0003785; F:actin monomer binding; TAS:RGD.
 GO:0030036; P:actin cytoskeleton organization; TAS:RGD.
 GO:0042989; P:sequestering of actin monomers; IEA:InterPro.
 GO:0007286; P:spermatid development; TAS:ProtInc. 

Interpro

 IPR001152; Thymosin_b4.
 IPR016323; Thymosin_b4_chordata. 

Pfam

 PF01290; Thymosin 

SMART

 SM00152; THY 

PROSITE

 PS00500; THYMOSIN_B4 

PRINTS