CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007498
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial 
Protein Synonyms/Alias
 Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma 
Gene Name
 Idh3g 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
115RRNRVALKGNIETNHacetylation[1]
159PGVVTRHKDIDILIVacetylation[1]
206RIAEYAFKLAQESGRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 NP_BIND 56 84 NAD (Potential).
 NP_BIND 309 316 ATP (Potential).
 METAL 254 254 Magnesium or manganese (By similarity).
 BINDING 136 136 Substrate (By similarity).
 BINDING 167 167 Substrate (By similarity).
 BINDING 254 254 Substrate (By similarity).
 MOD_RES 363 363 Phosphothreonine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MALKVAIAAG SAAKAIFKPA LLCRPWEVLA AHEAPRRSIS SQQTIPPSAK YGGRHTVTMI 60
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 120
NHDLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 180
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 240
ARYPQITFDS MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 300
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 360
MHTPDIGGQG TTSQAIQDII RHIRIINGRA VEA 393 
Gene Ontology
 GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.
 GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.
 GO:0006734; P:NADH metabolic process; IDA:RGD.
 GO:0045926; P:negative regulation of growth; IMP:RGD.
 GO:0006099; P:tricarboxylic acid cycle; IDA:RGD. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS