CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012961
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptic vesicle membrane protein VAT-1 homolog 
Protein Synonyms/Alias
 Mitofusin-binding protein; Protein MIB 
Gene Name
 Vat1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
241ASKHEVLKENGVTHPacetylation[1]
261TDYVDEIKKISPKGVacetylation[1]
266EIKKISPKGVDIVMDacetylation[1]
288AKGYHLLKPMGKVVTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. May negatively regulate mitochondrial fusion. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 31 31 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MSAEREATEA ATVAAAAEAR AETGAGEGAP SQPPTVEVAS DPQPPPAPEA SASASAPPLR 60
CLVLTGFGGY DKVKLQSRPA VPPAPGPGQV TLRVRACGLN FADLMGRQGL YDRLPPLPVT 120
PGMEGAGVVV AVGEGVSDRK AGDRVMVLNR SGMWQEEVTV PSAQTFLMPE AMTFEEAAAL 180
LVNYITAYMV LFDFGNLRPG HSVLVHMAAG GVGMAALQLC RTVENVTVFG TASASKHEVL 240
KENGVTHPID YHTTDYVDEI KKISPKGVDI VMDPLGGSDT AKGYHLLKPM GKVVTYGMAN 300
LLTGPKRNLM AMARTWWNQF SVTALQLLQA NRAVCGFHLG YLDGEVELVS RVVTHLLALY 360
NQGHIKPRID SVWPFEKVAD AMRQMQEKKN IGKVLLVPGP EKET 404 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010637; P:negative regulation of mitochondrial fusion; IEA:Compara. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom.
 IPR002364; Quin_OxRdtase/zeta-crystal_CS. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS01162; QOR_ZETA_CRYSTAL 
PRINTS