CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 
Protein Synonyms/Alias
 60 kDa BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B 
Gene Name
 SMARCD2 
Gene Synonyms/Alias
 BAF60B; PRO2451 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185SNTFSPSKAEGDSAGubiquitination[1]
205GGTPAGDKVASWELRubiquitination[1]
268ETDGFQVKRPGDLNVubiquitination[1]
430IESINQLKTQRDFMLubiquitination[1]
459RSQRRDLKIITDVIGubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). 
Sequence Annotation
 DOMAIN 307 382 SWIB.
 MOD_RES 217 217 Phosphothreonine.  
Keyword
 Alternative splicing; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPGP ALRGPGPAQY QRPGMSPGNR 60
MPMARLAGGT PCWLPIWCSS SASTWHPTHH DGSIPKTPAC APAQPPMPAQ RRGLKRRKMA 120
DKVLPQRIRE LVPESQAYMD LLAFERKLDQ TIARKRMEIQ EAIKKPLTQK RKLRIYISNT 180
FSPSKAEGDS AGTAGTPGGT PAGDKVASWE LRVEGKLLDD PSKQKRKFSS FFKSLVIELD 240
KELYGPDNHL VEWHRMPTTQ ETDGFQVKRP GDLNVKCTLL LMLDHQPPQY KLDPRLARLL 300
GVHTQTRAAI MQALWLYIKH NQLQDGHERE YINCNRYFRQ IFSCGRLRFS EIPMKLAGLL 360
QHPDPIVINH VISVDPNDQK KTACYDIDVE VDDPLKAQMS NFLASTTNQQ EIASLDVKIH 420
ETIESINQLK TQRDFMLSFS TDPQDFIQEW LRSQRRDLKI ITDVIGNPEE ERRAAFYHQP 480
WAQEAVGRHI FAKVQQRRQE LEQVLGIRLT 510 
Gene Ontology
 GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.
 GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.
 GO:0006337; P:nucleosome disassembly; IDA:BHF-UCL.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003121; SWIB_MDM2_domain. 
Pfam
 PF02201; SWIB 
SMART
  
PROSITE
  
PRINTS