CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009948
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 2 
Protein Synonyms/Alias
 HD2; YY1 transcription factor-binding protein 
Gene Name
 Hdac2 
Gene Synonyms/Alias
 Yy1bp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75YHSDEYIKFLRSIRPubiquitination[1]
221DIGAGKGKYYAVNFPacetylation[2]
243ESYGQIFKPIISKVMubiquitination[1]
451KARIEEDKKETEDKKacetylation[3]
481KTDPKGAKSEQLSNPacetylation[3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). 
Sequence Annotation
 REGION 9 322 Histone deacetylase.
 ACT_SITE 142 142 By similarity.
 MOD_RES 262 262 S-nitrosocysteine.
 MOD_RES 274 274 S-nitrosocysteine.
 MOD_RES 394 394 Phosphoserine.
 MOD_RES 422 422 Phosphoserine.
 MOD_RES 424 424 Phosphoserine.  
Keyword
 Acetylation; Chromatin regulator; Complete proteome; Hydrolase; Nucleus; Phosphoprotein; Reference proteome; Repressor; S-nitrosylation; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 488 AA 
Protein Sequence
MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 60
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 120
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 180
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 240
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVAK TFNLPLLMLG 300
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 360
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 420
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA 480
KSEQLSNP 488 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0005657; C:replication fork; IDA:MGI.
 GO:0016580; C:Sin3 complex; IEA:Compara.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0017053; C:transcriptional repressor complex; IPI:MGI.
 GO:0031490; F:chromatin DNA binding; IDA:MGI.
 GO:0004407; F:histone deacetylase activity; IDA:UniProtKB.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0055013; P:cardiac muscle cell development; IMP:MGI.
 GO:0016358; P:dendrite development; IMP:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.
 GO:0009913; P:epidermal cell differentiation; IGI:BHF-UCL.
 GO:0061029; P:eyelid development in camera-type eye; IGI:BHF-UCL.
 GO:0061198; P:fungiform papilla formation; IGI:BHF-UCL.
 GO:0060789; P:hair follicle placode formation; IGI:BHF-UCL.
 GO:0021766; P:hippocampus development; IGI:MGI.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0006344; P:maintenance of chromatin silencing; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IGI:BHF-UCL.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:MGI.
 GO:0010977; P:negative regulation of neuron projection development; IDA:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IGI:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL.
 GO:0048714; P:positive regulation of oligodendrocyte differentiation; IGI:MGI.
 GO:0045862; P:positive regulation of proteolysis; IEA:Compara.
 GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0090311; P:regulation of protein deacetylation; IGI:MGI.
 GO:0051896; P:regulation of protein kinase B signaling cascade; IMP:MGI.
 GO:0060297; P:regulation of sarcomere organization; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR003084; His_deacetylse_1.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.
 PR01271; HISDACETLASE.