CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Centrosomal protein of 97 kDa 
Protein Synonyms/Alias
  
Gene Name
 CEP97 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45IHTLILDKNQIIKLEubiquitination[1]
241DGYVISQKESLKAEWubiquitination[1]
493SVALGQDKVALQKLNacetylation[2]
493SVALGQDKVALQKLNubiquitination[1]
498QDKVALQKLNDAATKubiquitination[1]
505KLNDAATKLQACWRGacetylation[2]
505KLNDAATKLQACWRGubiquitination[1]
523RNYNPQAKDVRYEIRubiquitination[1, 3]
558ERDEERIKKFVQEEAubiquitination[1]
559RDEERIKKFVQEEAFubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 806 AA 
Protein Sequence
MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK LENLEKCKRL 60
IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE LVHLEWLNLA GNNLKAMEQI 120
NSCTALQHLD LSDNNISQIG DLSKLVSLKT LLLHGNIITS LRMAPAYLPR SLAILSLAEN 180
EIRDLNEISF LASLTELEQL SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ 240
KESLKAEWLY SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH 300
QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESESTFMPVA SGLSPLSPTV 360
ELRLQGINLG LEDDGVADES VKGLESQVLD KEEEQPLWAA NENSVQMMRS EINTEVNEKA 420
GLLPCPEPTI ISAILKDDNH SLTFFPESTE QKQSDIKKPE NTQPENKETI SQATSEKLPM 480
ILTQRSVALG QDKVALQKLN DAATKLQACW RGFYARNYNP QAKDVRYEIR LRRMQEHIVC 540
LTDEIRRLRK ERDEERIKKF VQEEAFRFLW NQVRSLQVWQ QTVDQRLSSW HTDVPPISST 600
LVPSKHPLFT QSQESSCDQN ADWFIASDVA PQEKSLPEFP DSGFHSSLTE QVHSLQHSLD 660
FEKSSTEGSE SSIMGNSIDT VRYGKESDLG DVSEEHGEWN KESSNNEQDN SLLEQYLTSV 720
QQLEDADERT NFDTETRDSK LHIACFPVQL DTLSDGASVD ESHGISPPLQ GEISQTQENS 780
KLNAEVQGQQ PECDSTFQLL HVGVTV 806 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 
Pfam
 PF00612; IQ
 PF12799; LRR_4 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ
 PS51450; LRR 
PRINTS