CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007563
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylmalonate semialdehyde dehydrogenase [acylating] 
Protein Synonyms/Alias
 MMSA dehydrogenase; MMSDH; MSDH; Malonate semialdehyde dehydrogenase [acetylating]; MSA dehydrogenase 
Gene Name
 iolA 
Gene Synonyms/Alias
 mmsA; yxdA; BSU39760; E83A 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
194KLVELFEKAGLPKGVacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. 
Sequence Annotation
 NP_BIND 176 180 NAD.
 ACT_SITE 284 284 Nucleophile.
 BINDING 382 382 NAD.  
Keyword
 3D-structure; Complete proteome; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
MAEIRKLKNY INGEWVESKT DQYEDVVNPA TKEVLCQVPI STKEDIDYAA QTAAEAFKTW 60
SKVAVPRRAR ILFNFQQLLS QHKEELAHLI TIENGKNTKE ALGEVGRGIE NVEFAAGAPS 120
LMMGDSLASI ATDVEAANYR YPIGVVGGIA PFNFPMMVPC WMFPMAIALG NTFILKPSER 180
TPLLTEKLVE LFEKAGLPKG VFNVVYGAHD VVNGILEHPE IKAISFVGSK PVGEYVYKKG 240
SENLKRVQSL TGAKNHTIVL NDANLEDTVT NIVGAAFGSA GERCMACAVV TVEEGIADEF 300
MAKLQEKVAD IKIGNGLDDG VFLGPVIRED NKKRTLSYIE KGLEEGARLV CDGRENVSDD 360
GYFVGPTIFD NVTTEMTIWK DEIFAPVLSV IRVKNLKEAI EIANKSEFAN GACLFTSNSN 420
AIRYFRENID AGMLGINLGV PAPMAFFPFS GWKSSFFGTL HANGKDSVDF YTRKKVVTAR 480
YPAPDFN 487 
Gene Ontology
 GO:0018478; F:malonate-semialdehyde dehydrogenase (acetylating) activity; IEA:HAMAP.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; IEA:HAMAP.
 GO:0019310; P:inositol catabolic process; IEA:HAMAP. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH.
 IPR023510; MeMal-semiAld_DH_GmP_bac. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS