| Tag | Content |
|---|
| CPLM ID | CPLM-014341 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipid phosphate phosphohydrolase 1 |
Protein Synonyms/Alias | 35 kDa PAP; mPAP; Hydrogen peroxide-inducible protein 53; Hic53; PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; PAP-2a; PAP2a |
Gene Name | Ppap2a |
Gene Synonyms/Alias | Hpic53; Lpp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 260 | THSYKERKEEDPHTT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P. |
Sequence Annotation | CARBOHYD 142 142 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 283 AA |
Protein Sequence | MFDKTRLPYV ALDVICVLLA GLPFAILTSR HTPFQRGIFC NDDSIKYPYK EDTIPYALLG 60
GIVIPFCIIV MSIGESLSVY FNVLHSNSFV GNPYIATIYK AVGAFLFGVS ASQSLTDIAK 120
YTIGSLRPHF LAICNPDWSK INCSDGYIED YICQGNEEKV KEGRLSFYSG HSSFSMYCML 180
FVALYLQARM KGDWARLLRP MLQFGLIAFS IYVGLSRVSD YKHHWSDVTV GLIQGAAMAI 240
LVALYVSDFF KDTHSYKERK EEDPHTTLHE TASSRNYSTN HEP 283 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:MGI. GO:0008195; F:phosphatidate phosphatase activity; ISS:UniProtKB. GO:0006672; P:ceramide metabolic process; TAS:MGI. GO:0006651; P:diacylglycerol biosynthetic process; TAS:MGI. GO:0006470; P:protein dephosphorylation; IDA:MGI. GO:0007165; P:signal transduction; TAS:MGI. GO:0006670; P:sphingosine metabolic process; TAS:MGI. |
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PROSITE | |
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