| Tag | Content |
|---|
| CPLM ID | CPLM-016029 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger FYVE domain-containing protein 16 |
Protein Synonyms/Alias | Endofin; Endosomal-associated FYVE domain protein |
Gene Name | Zfyve16 |
Gene Synonyms/Alias | Kiaa0305 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1245 | EMGKSCIKIPRKKYS | ubiquitination | [1] | | 1383 | DSEERKNKGVISSVD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity). |
Sequence Annotation | ZN_FING 735 793 FYVE-type.
MOD_RES 722 722 Phosphoserine.
MOD_RES 803 803 Phosphoserine (By similarity).
MOD_RES 833 833 Phosphoserine (By similarity).
MOD_RES 927 927 Phosphoserine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Endosome; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1528 AA |
Protein Sequence | MDSYFKAAVS GLDKLLDDFE QNPDKQDYLP DAYAFNQCSV SSESASPQLA LLSKDQRCIS 60
TCASSEACCE DANETFLEGK IHEGLTSRPN EKNVAGLDLL SSVDASTSDE IQPSCMRRCS 120
KPVCDLISDM GNLVHATNSE EDIKQLLPDD PKSSADTLIT LDSSSVSEAL TVSSVDCGSN 180
AVREEQNNIN AGIKNRDISI KELGVKVDMA LFDSCKYNRT ENLKDKIISN ELETVDFDMP 240
SVLMEQSSEM SNTKDNPQYK RLPCELLKDD GCLAEEKVAV AVNNTECLEE GGGSNTIAMP 300
CKLPENEGIS PSDPASKDEN FKLPDFPLQE NRTSVFMKQT VKEDSRNLDL KDNNDIVHVS 360
GDDVPPSLSC LSLSGSLCGS LIHNNEHSDI LPPNESEGQN NDAVTIHEEI QKSDVLDGET 420
DLSKKETCRS IFLQPVNEKK GEGKVEVEEM VISGESLESP EDASSAAAAG SPVALSAASV 480
PEAPGPCEGL TFPSSDMDGQ ELDYFNIDES MRSGILISDA ELDAFLKEQC LSNSNTMSAG 540
ENVNDSQLQM NQITMKGLHD ENAGDIYFNA EAGAAGENGG VGNCETSDKE NTENNGLSIG 600
EKGAIPTERE LSACQPDIRD ELPVPSIKTQ AVGGARPKQL LSLPPGTRSS KELNKPDVVD 660
VPESEPCTAN ATAVSTCSAD HIPDSQVSFN SNYIDIESNF EDGSSFVTAN KDSLPENKRK 720
ESLVLGQKQP TWVPDSEAPN CMNCQVKFTF TKRRHHCRAC GKVFCGVCCN RKCKLQYLEK 780
EARVCVICYE TINKAQAFER MMSPGGSCLK SNHSNECATD QPLQETQTSS TPSPTTLPIS 840
ALKQPNVEGP CSKEQKRVWF ADGILPNGEV ADTTKLSSGS KRCSDDFSPV LPDVPTMINK 900
VDRTHSPTVE KPNNGLGDII RSEISQSPTC HTAPVERLPG NTGTEGLPMP GPFTLEDDVF 960
VDSEEPSTPT VVPANSGLPV ASISDYRLLC SVAKCVCNNI SLLPDDDIGL PPLLATSGED 1020
GSVPVVQERP SHEQIILLLE GEGFPPATFV LNANLLVNVK LVLYSSEKYW YFSTNGLHGL 1080
GQAEIIVLLQ CLPNEDTVPK DIFRLFITIY KDALKGKYIE NLDNLTFTES FLNSKDHGGF 1140
LFITPTFQNL DGLPVPRSPF LCGILIQKLE IPWAKVFPMR LMLRLGAEYK AYPAPLTSVR 1200
GRKPLFGEIG HTIMNLLVDL RNYQYTLHNI DQLLIHMEMG KSCIKIPRKK YSDVMKVIHS 1260
SNEHVISIGA SFSTEADSHL VCVQSDGVYQ TQANSATGQP RKVTGASFVV FNGALKTSSG 1320
FLAKSSIVED GLMVQITPET MEGLRLALRE QKDFRIQCGK VDAVDLREYV DICWVDSEER 1380
KNKGVISSVD GMSVEGFPSE KIKLETDFET EEKTVKCTEV FYFLKDQDIS ILSSSYQFAK 1440
EIAVACSAAL CPHLRTLKSN RMNKIGLRVS IDTDMVEFQA GCEGQLLPQH YLNDLDSALI 1500
PVIHGGTSNS SLPLEIELAF FILENLSE 1528 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0005545; F:1-phosphatidylinositol binding; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Compara. GO:0008565; F:protein transporter activity; IEA:Compara. GO:0016197; P:endosomal transport; IEA:Compara. GO:0006622; P:protein targeting to lysosome; IEA:Compara. |
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