UniProt Accession

 Q76LV0_MOUSE; Q76LV0 

Genbank Protein ID

 AC159999; AC161120; AB072797 

Genbank Nucleotide ID

 BAC87835.1 

Protein Name

 Glutathione peroxidase 

Protein Synonyms/Alias

  

Gene Name

 Gpx4 

Gene Synonyms/Alias

 GPx4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
114	GHMVCLDKYRGFVCI	acetylation	[1]
173	PGSNQEIKEFAAGYN	ubiquitination	[2]
182	FAAGYNVKFDMYSKI	ubiquitination	[2]
218	GMLGNAIKWNFTKFL	ubiquitination	[2]
247	EEPQVIEKDLPCYL*	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Oxidoreductase; Peroxidase; Reference proteome; Selenium; Selenocysteine. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0004602; F:glutathione peroxidase activity; IDA:MGI.
 GO:0006325; P:chromatin organization; IDA:MGI.
 GO:0006979; P:response to oxidative stress; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IDA:MGI. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.