UniProt Accession

 EIF1A_HUMAN; Q8N9N8; B2R4N5; Q9BSC1 

Genbank Protein ID

 AK094129; AK311891; CH471076; BC005131 

Genbank Nucleotide ID

 BAC04293.1; BAG34832.1; EAW74478.1; AAH05131.1 

Protein Name

 Probable RNA-binding protein EIF1AD 

Protein Synonyms/Alias

 Eukaryotic translation initiation factor 1A domain-containing protein; Haponin 

Gene Name

 EIF1AD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	FLVSMPSKYRKNIWI	ubiquitination	[1, 2, 3]
98	DHVRSLQKEGFWPEA	ubiquitination	[1, 3]
112	AFSEVAEKHNNRNRQ	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Plays a role into cellular response to oxidative stress. Decreases cell proliferation. 

Sequence Annotation

 DOMAIN 5 89 S1-like.
 MOTIF 6 12 Nuclear localization signal (Potential).
 MOTIF 56 65 Nuclear localization signal (Potential).
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 159 159 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003743; F:translation initiation factor activity; IEA:InterPro. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR006196; RNA-binding_domain_S1_IF1.
 IPR001253; TIF_eIF-1A. 

Pfam

 PF01176; eIF-1a 

SMART

 SM00652; eIF1a 

PROSITE

 PS50832; S1_IF1_TYPE 

PRINTS