CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Deoxyribonuclease-2-alpha 
Protein Synonyms/Alias
 Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2 
Gene Name
 DNASE2 
Gene Synonyms/Alias
 DNASE2A; DNL2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52AQRGLQYKYLDESSGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. 
Sequence Annotation
 ACT_SITE 295 295 Probable.
 CARBOHYD 86 86 N-linked (GlcNAc...).
 CARBOHYD 212 212 N-linked (GlcNAc...).
 CARBOHYD 266 266 N-linked (GlcNAc...).
 CARBOHYD 290 290 N-linked (GlcNAc...).
 DISULFID 19 159 Potential.
 DISULFID 267 347 Potential.
 DISULFID 308 327 Potential.  
Keyword
 Apoptosis; Complete proteome; Developmental protein; Disulfide bond; Endonuclease; Glycoprotein; Hydrolase; Lysosome; Nuclease; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG 60
WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL 120
DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW 180
VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS 240
GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV 300
SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI 360 
Gene Ontology
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0004531; F:deoxyribonuclease II activity; TAS:ProtInc.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006308; P:DNA catabolic process; IEA:Compara.
 GO:0006259; P:DNA metabolic process; TAS:ProtInc.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR004947; DNase_II. 
Pfam
 PF03265; DNase_II 
SMART
  
PROSITE
  
PRINTS