CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014733
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SPT2 homolog 
Protein Synonyms/Alias
 Protein KU002155; SPT2 domain-containing protein 1 
Gene Name
 SPTY2D1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
289SMPGERIKAGSGNSSubiquitination[1]
582LPFPTGYKRQREYEEacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 582 582 N6-acetyllysine.
 MOD_RES 599 599 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 685 AA 
Protein Sequence
MDFREILMIA SKGQGVNNVP KRYSLAVGPP KKDPKVKGVQ SAAVQAFLKR KEEELRRKAL 60
EEKRRKEELV KKRIELKHDK KARAMAKRTK DNFHGYNGIP IEEKSKKRQA TESHTSQGTD 120
REYEMEEENE FLEYNHAESE QEYEEEQEPP KVESKPKVPL KSAPPPMNFT DLLRLAEKKQ 180
FEPVEIKVVK KSEERPMTAE ELREREFLER KHRRKKLETD GKLPPTVSKK APSQKESVGT 240
KLSKGSGDRH PSSKGMPLPH AEKKSRPSMA NEKHLALSSS KSMPGERIKA GSGNSSQPSL 300
REGHDKPVFN GAGKPHSSTS SPSVPKTSAS RTQKSAVEHK AKKSLSHPSH SRPGPMVTPH 360
NKAKSPGVRQ PGSSSSSAPG QPSTGVARPT VSSGPVPRRQ NGSSSSGPER SISGSKKPTN 420
DSNPSRRTVS GTCGPGQPAS SSGGPGRPIS GSVSSARPLG SSRGPGRPVS SPHELRRPVS 480
GLGPPGRSVS GPGRSISGSI PAGRTVSNSV PGRPVSSLGP GQTVSSSGPT IKPKCTVVSE 540
TISSKNIISR SSNGQMNGMK PPLSGYRAAQ GPQRLPFPTG YKRQREYEEE DDDDDEYDSE 600
MEDFIEDEGE PQEEISKHIR EIFGYDRKKY KDESDYALRY MESSWKEQQK EEAKSLRLGM 660
QEDLEEMRRE EEEMQRRRAK KLKRR 685 
Gene Ontology
  
Interpro
 IPR013256; Chromatin_SPT2. 
Pfam
 PF08243; SPT2 
SMART
 SM00784; SPT2 
PROSITE
  
PRINTS