| Tag | Content |
|---|
| CPLM ID | CPLM-004148 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldehyde dehydrogenase, cytosolic 1 |
Protein Synonyms/Alias | ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A7; Aldehyde dehydrogenase phenobarbital-inducible |
Gene Name | Aldh1a7 |
Gene Synonyms/Alias | Aldh-pb; Aldh1; Aldh1a4 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 17 | PAPLANLKIQHTKIF | acetylation | [1] | | 91 | ERGCLLNKLADLMER | acetylation | [1] | | 255 | TEVGKLIKEAAGKSN | acetylation | [1] | | 348 | SQGPQIDKEQHAKIL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal. |
Sequence Annotation | NP_BIND 246 251 NAD (By similarity).
ACT_SITE 269 269 Proton acceptor (By similarity).
ACT_SITE 303 303 Nucleophile (By similarity). |
Keyword | Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 501 AA |
Protein Sequence | MSSPAQPAVP APLANLKIQH TKIFINNEWH NSLNGKKFPV INPATEEVIC HVEEGDKADV 60
DKAVKAARQA FQIGSPWRTM DASERGCLLN KLADLMERDR VLLATMESMN AGKIFTHAYL 120
LDTEVSIKAL KYFAGWADKI HGQTIPSDGD VFTYTRREPI GVCGQIIPWN GPLILFIWKI 180
GAALSCGNTV IVKPAEQTPL TALYMASLIK EAGFPPGVVN VVPGYGSTAG AAISSHMDID 240
KVSFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 300
QICVAASRLF VEESIYDEFV RRSVERAKKY VLGNPLDSGI SQGPQIDKEQ HAKILDLIES 360
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSIDEVIKR 420
ANNTPYGLAA GVFTKDLDRA ITVSSALQAG TVWVNCYLTL SVQCPFGGFK MSGNGREMGE 480
QGVYEYTELK TVAMKISQKN S 501 |
Gene Ontology | GO:0005829; C:cytosol; NAS:RGD. GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IDA:RGD. GO:0018479; F:benzaldehyde dehydrogenase (NAD+) activity; IDA:RGD. GO:0042802; F:identical protein binding; IDA:RGD. GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. GO:0035106; P:operant conditioning; IEP:RGD. GO:0051289; P:protein homotetramerization; IDA:RGD. |
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PROSITE | |
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